Zobrazeno 1 - 10
of 1 197
pro vyhledávání: '"cytochrome P450s"'
Autor:
Collins, Joseph M., Wang, Danxin ∗
Publikováno v:
In Drug Metabolism and Disposition January 2025 53(1)
Discovery and biosynthesis of bacterial drimane-type sesquiterpenoids from Streptomyces clavuligerus
Autor:
Dongxu Zhang, Wenyu Du, Xingming Pan, Xiaoxu Lin, Fang-Ru Li, Qingling Wang, Qian Yang, Hui-Min Xu, Liao-Bin Dong
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 815-822 (2024)
Drimane-type sesquiterpenoids (DMTs) are characterized by a distinctive 6/6 bicyclic skeleton comprising the A and B rings. While DMTs are commonly found in fungi and plants, their presence in bacteria has not been reported. Moreover, the biosyntheti
Externí odkaz:
https://doaj.org/article/b3b62f2db2c2461b938c840da06a8a8e
Autor:
Joseph M. Collins, Danxin Wang
Publikováno v:
Molecules, Vol 29, Iss 22, p 5407 (2024)
CYP3As are important drug-metabolizing enzymes in the liver. The causes for large inter-person variability in CYP3A expression/activity remain poorly understood. DNA methylation broadly regulates gene expression and the developmental transition from
Externí odkaz:
https://doaj.org/article/a0feb471687f49d68f8827995fdea54e
Autor:
Chuanteng Ma, Wenxue Wang, Kaijin Zhang, Falei Zhang, Yimin Chang, Chunxiao Sun, Qian Che, Tianjiao Zhu, Guojian Zhang, Dehai Li
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract Dimeric indole‐containing diketopiperazines (di‐DKPs) are a diverse group of natural products produced through cytochrome P450‐catalyzed C–C or C–N coupling reactions. The regio‐ and stereoselectivity of these reactions plays a s
Externí odkaz:
https://doaj.org/article/bf2cc848f3284755ba99c1a63cedefab
Autor:
Yahya F. Jamous, Badrah S. Alghamdi, Yazun Jarrar, Emad A. Hindi, Mohammad Z. Alam, Gamal S. Abd El-Aziz, Rabee F. Ibrahim, Refal Bakhlgi, Salha M. Algarni, Hanin A. AboTaleb
Publikováno v:
Pharmaceuticals, Vol 17, Iss 11, p 1454 (2024)
Background: Etoricoxib is a widely used anti-inflammatory drug, but its safety profile concerning cardiovascular and renal health remains inadequately explored. This study aimed to assess the nephro- and cardiotoxic effects of etoricoxib in a murine
Externí odkaz:
https://doaj.org/article/7f256c0d40ba47498a5c75d8e7e0d227
Publikováno v:
Agronomy, Vol 14, Iss 10, p 2399 (2024)
Green foxtail is a troublesome weed in crop fields across China. A nova target HPPD inhibitor is widely used to control weeds in agricultural production. Mesotrione, an HPPD inhibitor, cannot control green foxtail effectively under the recommended fi
Externí odkaz:
https://doaj.org/article/8223d35aa2e34d64b31248d8542fcbdb
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 9, Pp 7130-7146 (2023)
Cytochromes P450 (CYP) and UDP-glucuronosyltransferases (UGT) are two enzyme families that play an important role in drug metabolism, catalyzing either the functionalization or glucuronidation of xenobiotics. However, their mutual interactions are po
Externí odkaz:
https://doaj.org/article/f5896274db3e4f09b2400e3893d038a9
Autor:
Qi Zhang, Shuang Wu, Qiubing Chen, Yahong Zhang, Cai Zhang, Runting Yin, Zhen Ouyang, Yuan Wei
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1505 (2024)
The prevalence of excessive drinking-related alcoholic liver disease (ALD) is rising, yet therapeutic options remain limited. High alcohol consumption and consequent oxidative metabolism by cytochrome P450 (CYP) can lead to extremely high levels of r
Externí odkaz:
https://doaj.org/article/41c3468ebf3b4aa39ec787ce3e4d5772
Publikováno v:
Molecules, Vol 29, Iss 11, p 2480 (2024)
Cytochrome P450s (P450s), a superfamily of heme-containing enzymes, existed in animals, plants, and microorganisms. P450s can catalyze various regional and stereoselective oxidation reactions, which are widely used in natural product biosynthesis, dr
Externí odkaz:
https://doaj.org/article/f584716b35a243bdb84992a224fe0c29
Publikováno v:
Journal of Medicinal Plants, Vol 21, Iss 84, Pp 26-38 (2022)
Background: Cytochrome P450s have essential roles in oxidative reactions during the biosynthesis of secondary metabolites, such as terpenoids. Objective: This research was aimed to identify the gene CYP72A154 as a gene involved in the glycyrrhizin bi
Externí odkaz:
https://doaj.org/article/69a8978a3737488e9960c846db6ed848