Zobrazeno 1 - 10
of 770
pro vyhledávání: '"cytochrome P450 3A4"'
Publikováno v:
Phytomedicine Plus, Vol 5, Iss 1, Pp 100681- (2025)
Background: Wild edible plants (WEPs) including herbs provide staple foods as well as income for local communities on the African continent. However, these commonly used plant materials interact with orthodox or conventional drugs through both p-glyc
Externí odkaz:
https://doaj.org/article/e8877085fd9e4682a858b0df50c7f18c
Autor:
Sara Maluck, Rivka Bobrovsky, Miklós Poór, Roman W. Lange, Torsten Steinmetzer, Ákos Jerzsele, András Adorján, Dávid Bajusz, Anita Rácz, Erzsébet Pászti-Gere
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 2075 (2024)
Inhibitors of the serine protease furin have been widely studied as antimicrobial agents due to their ability to block the cleavage and activation of certain viral surface proteins and bacterial toxins. In this study, the antipseudomonal effects and
Externí odkaz:
https://doaj.org/article/c3d87a5f787f41938ffa7fcfd80fda1e
Autor:
Nicholas van Eijk, Luna C. Schmacke, Torsten Steinmetzer, Oliver Pilgram, Miklós Poór, Erzsébet Pászti-Gere
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115761- (2023)
The outbreak of coronavirus disease 2019 (COVID-19) pandemic strongly stimulated the development of small molecule antivirals selectively targeting type II transmembrane serine proteases (TTSP), required for the host-cell entry of numerous viruses. A
Externí odkaz:
https://doaj.org/article/2cba99daeb6c428d8c10277c3f18aaa3
Autor:
Xuefen Yin, Brian Cicali, Leyanis Rodriguez-Vera, Viera Lukacova, Rodrigo Cristofoletti, Stephan Schmidt
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 737 (2024)
Carbamazepine (CBZ) is commonly prescribed for epilepsy and frequently used in polypharmacy. However, concerns arise regarding its ability to induce the metabolism of other drugs, including itself, potentially leading to the undertreatment of co-admi
Externí odkaz:
https://doaj.org/article/aa09ac29b3c6427e9fd2dfccb09dc310
Autor:
Wei Pan, Lei Feng, Cheng-Peng Sun, Xiang-Ge Tian, Chao Shi, Chao Wang, Xia Lv, Yan Wang, Shan-Shan Huang, Bao-Jing Zhang, Jing Ning, Xiao-Chi Ma
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 10, Pp 105156- (2023)
The interaction between herbs and clinical drugs is one of the risk factors for adverse drug reactions. In the present study, the inhibitory effects of 47 tetracyclic triterpenoids toward the main drug-metabolizing CYPs in humans were investigated. M
Externí odkaz:
https://doaj.org/article/c045e2b969e046859cd83bc06f880791
Publikováno v:
Liver Research, Vol 6, Iss 4, Pp 251-257 (2022)
Background and aims: The herbal supplement Gancao, also known as licorice, belongs to the genus Glycyrrhiza and has been used worldwide for its hepatoprotective effect. Recent studies have raised concerns about potential herb-drug interactions associ
Externí odkaz:
https://doaj.org/article/b8cfc72ec847483fa6c29ed759363669
Akademický článek
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Akademický článek
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Autor:
Seulgi Lee, Bernie Byeonghoon Park, Hongmok Kwon, Vitchan Kim, Jang Su Jeon, Rowoon Lee, Milan Subedi, Taehyeong Lim, Hyunsoo Ha, Dongju An, Jaehoon Kim, Donghak Kim, Sang Kyum Kim, Seyun Kim, Youngjoo Byun
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 269-279 (2022)
Inositol hexakisphosphate kinase (IP6K) is an important mammalian enzyme involved in various biological processes such as insulin signalling and blood clotting. Recent analyses on drug metabolism and pharmacokinetic properties on TNP (N2-(m-trifluoro
Externí odkaz:
https://doaj.org/article/b92d8702f213451b962add5ca26a8351
Autor:
Shoko Miyata, Noriaki Saku, Saeko Akiyama, Palaksha Kanive Javaregowda, Kenta Ite, Nagisa Takashima, Masashi Toyoda, Kei Yura, Tohru Kimura, Hiroshi Nishina, Atsuko Nakazawa, Mureo Kasahara, Hidenori Nonaka, Tohru Kiyono, Akihiro Umezawa
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Background Many drugs have the potential to induce the expression of drug-metabolizing enzymes, particularly cytochrome P450 3A4 (CYP3A4), in hepatocytes. Hepatocytes can be accurately evaluated for drug-mediated CYP3A4 induction; this is th
Externí odkaz:
https://doaj.org/article/53e970eb9c7b483b8c5026ed976e2f1c