Zobrazeno 1 - 10
of 357
pro vyhledávání: '"cyp46a1"'
Autor:
Polina Petkova-Kirova, Anastasia Kolchina, Stephan Baas, Gudrun Wagenpfeil, Marcus Michael Unger, Julia Maria Schulze-Hentrich, Rita Bernhardt
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Besides being an essential structural component of plasma membranes and the precursor of many functional compounds and signaling molecules, cholesterol was also proposed to play a role in the etiology and/or manifestation of Parkinson’s disease (PD
Externí odkaz:
https://doaj.org/article/4d0acad73c67452e94486d478f690e86
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2024)
Cholesterol is an essential component of cellular membranes, crucial for maintaining their structural and functional integrity. It is especially important for nervous tissues, including the retina, which rely on high amounts of plasma membranes for t
Externí odkaz:
https://doaj.org/article/81036171ccfd4f3f820910db8150241e
Autor:
Alan J. Lerner, Steven E. Arnold, Erin Maxfield, Aaron Koenig, Maria E. Toth, Brooke Fortin, Natalia Mast, Bianca A. Trombetta, John Denker, Andrew A. Pieper, Curtis Tatsuoka, Sangeetha Raghupathy, Irina A. Pikuleva
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2022)
Abstract Background Efavirenz is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is a CNS-specific enzyme that metabolizes cholesterol to 24-hydroxycholesterol (24HC). We have previously shown that allosteric CYP46A1 activation by low-dose efavi
Externí odkaz:
https://doaj.org/article/be51f0c921904c6eb9b8ba7aa6a50ed7
Akademický článek
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Autor:
Nicole El-Darzi, Natalia Mast, Sandra S. Hammer, Tim F. Dorweiler, Julia V. Busik, Irina A. Pikuleva
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 2, Pp 100323- (2023)
CYP46A1 is a CNS-specific enzyme, which eliminates cholesterol from the brain and retina by metabolism to 24-hydroxycholesterol, thus contributing to cholesterol homeostasis in both organs. 2-Hydroxypropyl-β-cyclodextrin (HPCD), a Food and Drug Admi
Externí odkaz:
https://doaj.org/article/416b987dee114e0eaef22c32059e6f1f
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Genetic and environmental factors lead to the manifestation of Parkinson’s disease (PD) but related mechanisms are only rudimentarily understood. Cytochromes P450 (P450s) are involved in the biotransformation of toxic compounds and in many physiolo
Externí odkaz:
https://doaj.org/article/edb2071e2e584ffdb6c8816e3d847289
Autor:
Jie Du, Xiaodong Chen, Yongshun Zhao, Tingting Zhao, Dalong Wang, Zujia Chen, Changyuan Wang, Qiang Meng, Jialin Yao, Huijun Sun, Kexin Liu, Jingjing Wu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
CYP46A1 is a brain-specific enzyme responsible for cholesterol homeostasis. Inhibition of CYP46A1 activity serves as a therapeutic target for excitatory neurotoxicity. Sesame is a common medicine and food resource; its component lignans possess vario
Externí odkaz:
https://doaj.org/article/48b29ec92e544cb4a35dcf29954f4510
Publikováno v:
Avicenna Journal of Phytomedicine, Vol 11, Iss 5, Pp 473-483 (2021)
Objective: Regulation of cholesterol level is essential for the brain optimal function. The beneficial effect of garlic consumption on cholesterol homeostasis is well known; however, the molecular mechanism to support its properties is unclear. Here,
Externí odkaz:
https://doaj.org/article/6db91e2219e84b2997b51714378277f1
Autor:
Nicole El-Darzi, Natalia Mast, David A. Buchner, Aicha Saadane, Brian Dailey, Georgios Trichonas, Irina A. Pikuleva
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
A small dose of the anti-HIV drug efavirenz (EFV) was previously discovered to activate CYP46A1, a cholesterol-eliminating enzyme in the brain, and mitigate some of the manifestation of Alzheimer’s disease in 5XFAD mice. Herein, we investigated the
Externí odkaz:
https://doaj.org/article/ed746dc3793c44e1a259e662f90f526e
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Externí odkaz:
https://doaj.org/article/eb9e020a4e4e469a981b8dbd84c50e4d