Prenatal p25-activated Cdk5 induces pituitary tumorigenesis through MCM2 phosphorylation-mediated cell proliferation.

Autor: Huang Y; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Neurology, Jiangmen Central Hospital, Jiangmen, China., Wang Q; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China., Zhou W; Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China., Jiang Y; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China., He K; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Southern Medical University, Guangzhou, China., Huang W; Department of Neurology, the First People's Hospital of Shunde, Southern Medical University, Guangzhou, China., Feng Y; Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China., Wu H; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Liu L; Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China., Pan Y; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Huang Y; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Chen Z; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Li W; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Huang Y; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Lin G; Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China., Zhang Y; Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China., Ren Y; Central Laboratory, Southern Medical University, Guangzhou, China., Xu K; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Yu Y; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States., Peng Y; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China., Pan X; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Southern Medical University, Guangzhou, China; Precision Regenerative Medicine Research Centre, Medical Science Division, and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, China; China Ministry Education Key Laboratory of Infectious Diseases Research in South China, Southern Medical University, Guangzhou, China. Electronic address: panxinghua@must.edu.mo., Pan S; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: pansuyue@smu.edu.cn., Hu H; Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China. Electronic address: huhl@sustech.edu.cn., Hu Y; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: yafanghu@smu.edu.cn.

Publikováno v: Neoplasia (New York, N.Y.) [Neoplasia] 2024 Nov; Vol. 57, pp. 101054. Date of Electronic Publication: 2024 Oct 03.

Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition.

Autor: Yuzhalin AE; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lowery FJ; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Saito Y; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yuan X; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yao J; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Duan Y; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ding J; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Acharya S; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhang C; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fajardo A; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chen HN; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wei Y; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sun Y; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhang L; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Xiao Y; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Li P; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lorenzi PL; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Huse JT; Departments of Pathology and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fan H; Center for Precision Health, McWilliams School of Biomedical Informatics, Houston, TX, USA.; John P and Katherine G McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA., Zhao Z; Center for Precision Health, McWilliams School of Biomedical Informatics, Houston, TX, USA., Hung MC; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Graduate Institute of Biomedical Sciences, Research Center for Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung City, Taiwan., Yu D; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. dyu@mdanderson.org.

Publikováno v: Nature cell biology [Nat Cell Biol] 2024 Oct; Vol. 26 (10), pp. 1773-1789. Date of Electronic Publication: 2024 Sep 20.

Reciprocal regulation of oxidative stress and mitochondrial fission augments parvalbumin downregulation through CDK5-DRP1- and GPx1-NF-κB signaling pathways.

Autor: Wang SH; Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, 24252, South Korea., Lee DS; Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, 24252, South Korea., Kim TH; Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, 24252, South Korea., Kim JE; Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, 24252, South Korea. jieunkim@hallym.ac.kr., Kang TC; Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, 24252, South Korea. tckang@hallym.ac.kr.

Publikováno v: Cell death & disease [Cell Death Dis] 2024 Sep 30; Vol. 15 (9), pp. 707. Date of Electronic Publication: 2024 Sep 30.

CDK5 as a therapeutic tool for the treatment of Alzheimer's disease: A review.

Autor: Garemilla S; Department of Life Sciences, GITAM School of Sciences, GITAM (Deemed to Be) University, Visakhapatnam, India; The George Washington University, Washington, DC, USA., Kumari R; Department of Life Sciences, GITAM School of Sciences, GITAM (Deemed to Be) University, Visakhapatnam, India; Department of Biotechnology, Savitribai Phule Pune University, Pune, Maharashtra, India., Kumar R; Department of Life Sciences, GITAM School of Sciences, GITAM (Deemed to Be) University, Visakhapatnam, India. Electronic address: rkumar2@gitam.edu.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2024 Sep 05; Vol. 978, pp. 176760. Date of Electronic Publication: 2024 Jun 18.

Ubiquitin-specific protease 1 facilitates hepatocellular carcinoma progression by modulating mitochondrial fission and metabolic reprogramming via cyclin-dependent kinase 5 stabilization.

Autor: Bian S; Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.; Department of Oncology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China., Ni W; Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China., Zhou L; Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.; Department of Oncology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China., Tong Y; Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.; Department of Oncology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China., Dai C; Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.; Department of Oncology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China., Zhao X; Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China., Qiang Y; Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.; Department of Oncology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China., Gao J; Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.; Department of Oncology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China., Xiao Y; Department of Interventional Radiology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China., Liu W; School of Life Sciences, Nantong Laboratory of Development and Diseases, Nantong University, Nantong, China., Chen C; School of Life Sciences, Nantong Laboratory of Development and Diseases, Nantong University, Nantong, China., Lin S; Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.; Fudan Zhangjiang Institute, Shanghai, China., Gong J; Department of Pharmaceutics, School of Pharmacy & Shanghai Pudong Hospital, Fudan University, Shanghai, China.; Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, China., Zhao S; Department of Interventional Radiology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China., Chen Y; Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China., Lin Z; Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China., Liu D; School of Life Sciences, Nantong Laboratory of Development and Diseases, Nantong University, Nantong, China. liudongtom@gmail.com., Zhao H; Department of Interventional Radiology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China. zhaohui800@163.com., Zheng W; Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China. wenjiezheng@ntu.edu.cn.; Department of Oncology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China. wenjiezheng@ntu.edu.cn.

Publikováno v: Cell death and differentiation [Cell Death Differ] 2024 Sep; Vol. 31 (9), pp. 1202-1218. Date of Electronic Publication: 2024 Jul 15.