Zobrazeno 1 - 10
of 68
pro vyhledávání: '"cyclin-dependent kinase 2 (Cdk2)"'
Autor:
Robert F. Brooks
Publikováno v:
Cell Division, Vol 18, Iss 1, Pp 1-6 (2023)
Abstract Attempts to map the Restriction Point in the mammalian cell cycle typically involve stimulating quiescent cells with mitogens for increasing intervals, removing the stimulus and then determining the proportion of cells that reach S phase at
Externí odkaz:
https://doaj.org/article/9d126629450c4f398c82f1d26d2d8a51
Publikováno v:
Aging (Albany NY)
Among the many factors that promote cellular senescence, reactive oxygen species (ROS) are a focus of intense research because of their critical role in accelerating cellular senescence and initiating senescence-related diseases that can be fatal. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b459bd8a5990db037348403bcb3721
http://europepmc.org/articles/PMC6756887
http://europepmc.org/articles/PMC6756887
Akademický článek
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Autor:
Hanne Leysen, Jhana O. Hendrickx, Paula Santos-Otte, Stuart Maudsley, Jaana van Gastel, Bronwen Martin
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1265-1277 (2019)
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1265-1277 (2019)
Aging is a complex biological process that is inevitable for nearly all organisms. Aging is the strongest risk factor for development of multiple neurodegenerative disorders, cancer and cardiovascular disorders. Age-related disease conditions are mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df108c2d57f738f31f95e73a11100b3
https://doi.org/10.1016/j.csbj.2019.08.005
https://doi.org/10.1016/j.csbj.2019.08.005
Publikováno v:
Amino Acids
Amino Acids, Springer Verlag, 2019, 51 (7), pp.1065-1079. ⟨10.1007/s00726-019-02747-w⟩
Amino Acids, 2019, 51 (7), pp.1065-1079. ⟨10.1007/s00726-019-02747-w⟩
Amino Acids, Springer Verlag, 2019, 51 (7), pp.1065-1079. ⟨10.1007/s00726-019-02747-w⟩
Amino Acids, 2019, 51 (7), pp.1065-1079. ⟨10.1007/s00726-019-02747-w⟩
International audience; Post-Translational Modifications (PTMs) are known to play a critical role in the regulation of the protein functions. Their impact on protein structures, and their link to disorder regions have already been spotted on the past
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8006f6360b8678cee8f81ce3943ba2
https://www.hal.inserm.fr/inserm-02266176/document
https://www.hal.inserm.fr/inserm-02266176/document
Autor:
Neil Portman, Solomon Tadesse, Shudong Wang, C. Elizabeth Caldon, Abel Tesfaye Anshabo, Wayne D. Tilley, Elgene Lim
Publikováno v:
Drug discovery today. 25(2)
Cyclin-dependent kinase 2 (CDK2) plays a pivotal part in cell cycle regulation and is involved in a range of biological processes. CDK2 interacts with and phosphorylates proteins in pathways such as DNA damage, intracellular transport, protein degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51cb909d2d99af6248b05fbf0ad59301
https://pubmed.ncbi.nlm.nih.gov/31839441
https://pubmed.ncbi.nlm.nih.gov/31839441
Publikováno v:
Oncology Research
Raltitrexed (RTX) is an antimetabolite drug used as a chemotherapeutic agent for treating colorectal cancer, malignant mesothelioma, and gastric cancer. The antitumor capacity of RTX is attributed to its inhibitory activity on thymidylate synthase (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98972fcece88fb5ff687fd775b96754
http://europepmc.org/articles/PMC7838684
http://europepmc.org/articles/PMC7838684
Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S- and M-phases of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is critically associated with tumor growth in multiple cancer types. Alth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62aee395c474189a11d98c777ab83893
https://hdl.handle.net/11541.2/135589
https://hdl.handle.net/11541.2/135589
Akademický článek
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Akademický článek
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