Zobrazeno 1 - 10
of 429
pro vyhledávání: '"cyclin-dependent kinase (CDK)"'
Autor:
Diana Malarikova, Radek Jorda, Kristyna Kupcova, Jana Senavova, Alexandra Dolnikova, Eva Pokorna, Dmitry Kazantsev, Kristina Nozickova, Dana Sovilj, Celine Bellanger, David Chiron, Ladislav Andera, Vladimir Krystof, Miroslav Strnad, Karel Helman, Magdalena Klanova, Marek Trneny, Ondrej Havranek, Pavel Klener
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-4 (2024)
Abstract Background Mantle cell lymphoma (MCL) is a chronically relapsing malignancy with deregulated cell cycle progression. We analyzed efficacy, mode of action, and predictive markers of susceptibility to palbociclib, an approved CDK 4/6 inhibitor
Externí odkaz:
https://doaj.org/article/66f0f83138da43c8bb386bfcf004df4c
Autor:
Martin Schütz, Christina Wangen, Mona Sommerer, Melanie Kögler, Jan Eickhoff, Carsten Degenhart, Bert Klebl, Zin Naing, Ece Egilmezer, Stuart T. Hamilton, William D. Rawlinson, Heinrich Sticht, Manfred Marschall
Publikováno v:
Virus Research, Vol 335, Iss , Pp 199200- (2023)
Human cytomegalovirus (HCMV) infection is shaped by a tightly regulated interplay between viral and cellular proteins. Distinct kinase activities, such as the viral cyclin-dependent kinase ortholog (vCDK) pUL97 and cellular CDK7 are both crucial for
Externí odkaz:
https://doaj.org/article/ac8f839330fc4cb29be6a6ece1547fd9
Publikováno v:
Breast, Vol 62, Iss , Pp 162-169 (2022)
Background: Cyclin-Dependent Kinase (CDK) 4/6 inhibitors have shown significant clinical activity in cancer patients. However, some concerns regarding rare adverse events (AEs) have occurred including interstitial lung disease (ILD)/pneumonitis, for
Externí odkaz:
https://doaj.org/article/ac50673f32454c1488c1188ef3c6ae54
Autor:
Tianyan Wang, Martuza Sarwar, Jonathan B Whitchurch, Hilary M Collins, Tami Green, Julius Semenas, Amjad Ali, Christopher J Roberts, Ryan D Morris, Madlen Hubert, Sa Chen, Zahra El-Schich, Anette G Wingren, Thomas Grundström, Richard Lundmark, Nigel P Mongan, Lena Gunhaga, David M Heery, Jenny L Persson
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
PIP5K1α has emerged as a promising drug target for the treatment of castration-resistant prostate cancer (CRPC), as it acts upstream of the PI3K/AKT signaling pathway to promote prostate cancer (PCa) growth, survival and invasion. However, little is
Externí odkaz:
https://doaj.org/article/6f00bee0afbc4bf1a1d8d8f354c3e273
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3555 (2022)
Cyclin-dependent kinases (CDKs) are pivotal mediators and effectors of the DNA damage response (DDR) that regulate both the pathway components and proteins involved in repair processes. Synthetic lethality (SL) describes a situation in which two gene
Externí odkaz:
https://doaj.org/article/4f85ea0056f143d0aeaecf98c8d30812
Akademický článek
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Autor:
Ruiqi Liao, Craig A. Mizzen
Publikováno v:
Epigenetics & Chromatin, Vol 10, Iss 1, Pp 1-21 (2017)
Abstract Background Structural variation among histone H1 variants confers distinct modes of chromatin binding that are important for differential regulation of chromatin condensation, gene expression and other processes. Changes in the expression an
Externí odkaz:
https://doaj.org/article/58d64fc649ec4ccebd1974cf5926d5a9
Akademický článek
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Akademický článek
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Autor:
Monika Nováková, Marek Hampl, Dávid Vrábel, Jan Procházka, Silvia Petrezselyová, Michaela Procházková, Radislav Sedláček, Michaela Kavková, Tomáš Zikmund, Jozef Kaiser, Hsien-Chia Juan, Ming-Ji Fann, Marcela Buchtová, Jiří Kohoutek
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Congenital heart defects, dysmorphic facial features and intellectual developmental disorders (CHDFIDD) syndrome in humans was recently associated with mutation in CDK13 gene. In order to assess the loss of function of Cdk13 during mouse development,
Externí odkaz:
https://doaj.org/article/4d41af9129ff4519a62d72b8f5b0b1e8