Zobrazeno 1 - 10
of 1 058
pro vyhledávání: '"cyclic stretch"'
Autor:
Manijeh Khanmohammadi, Habiba Danish, Nadia Chandra Sekar, Sergio Aguilera Suarez, Chanly Chheang, Karlheinz Peter, Khashayar Khoshmanesh, Sara Baratchi
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Neutrophils, the most abundant leukocytes circulating in blood, contribute to host defense and play a significant role in chronic inflammatory disorders. They can release their DNA in the form of extracellular traps (NETs), which
Externí odkaz:
https://doaj.org/article/3af4aa213671408c92e0267afd734f77
Autor:
Giuseppina Fanelli, Giulia Alloisio, Veronica Lelli, Stefano Marini, Sara Rinalducci, Magda Gioia
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2024)
There has been an increasing focus on cancer mechanobiology, determining the underlying-induced changes to unlock new avenues in the modulation of cell malignancy. Our study used LC-MS untargeted metabolomic approaches and real-time polymerase chain
Externí odkaz:
https://doaj.org/article/a32c24ee698f40999cf96577ae714983
Publikováno v:
Physiological Reports, Vol 12, Iss 7, Pp n/a-n/a (2024)
Abstract Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) are rapidly gaining ground in the treatment of heart failure (HF) with reduced ejection fraction (HFrEF) and acute myocardial infarction (AMI) by an unknown mechanism. Upregulation of Na+/
Externí odkaz:
https://doaj.org/article/6d2bb96610a247ef999a156948b8d728
Autor:
Xiaoling Li, Mengnan Wang, Jan-Ole Kalina, Benedikt Preckel, Markus W. Hollmann, Martin Albrecht, Coert J. Zuurbier, Nina C. Weber
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 102979- (2024)
Background: Empagliflozin (EMPA) ameliorates reactive oxygen species (ROS) generation in human endothelial cells (ECs) exposed to 10 % stretch, but the underlying mechanisms are still unclear. Pathological stretch is supposed to stimulate protein kin
Externí odkaz:
https://doaj.org/article/2f33de2efafb4ef0b4548402cf79295b
Autor:
Xi Ran, Sabine Müller, Coy Brunssen, Robert Huhle, Martin Scharffenberg, Christian Schnabel, Thea Koch, Marcelo Gama de Abreu, Henning Morawietz, Jorge M. C. Ferreira, Jakob Wittenstein
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Background: Mechanical ventilation (MV) is a life supporting therapy but may also cause lung damage. This phenomenon is known as ventilator-induced lung injury (VILI). A potential pathomechanisms of ventilator-induced lung injury may be the stretch-i
Externí odkaz:
https://doaj.org/article/feb974d320a6413b9dd741435a3ddb89
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Due to its viscoelastic properties, the aorta aids in dampening blood pressure pulsatility. At the level of resistance-arteries, the pulsatile flow will be transformed into a continuous flow to allow for optimal perfusion of end organs such as the ki
Externí odkaz:
https://doaj.org/article/683eb2058dc74387803314d873822cd9
Autor:
Anna Nakagawa, Sumio Hayakawa, Yinglan Cheng, Azusa Honda, Ryo Yuzawa, Rei Ogawa, Yumiko Oishi
Publikováno v:
FEBS Open Bio, Vol 13, Iss 1, Pp 185-194 (2023)
Macrophages distributed in tissues throughout the body contribute to homeostasis. In the inflammatory state, macrophages undergo mechanical stress that regulates the signal transduction of immune responses and various cellular functions. However, the
Externí odkaz:
https://doaj.org/article/6dafd7e7c9714fde946bed9b0195ca0e
Autor:
Tao Tang, Zhengya Zhu, Zhongyuan He, Fuan Wang, Hongkun Chen, Shengkai Liu, Mingbin Zhan, Jianmin Wang, Wei Tian, Dafu Chen, Xinbao Wu, Xizhe Liu, Zhiyu Zhou, Shaoyu Liu
Publikováno v:
JOR Spine, Vol 6, Iss 2, Pp n/a-n/a (2023)
Abstract Background Ossification of the posterior longitudinal ligaments (OPLL) is common disorder characterized by heterotopic ossification of the spinal ligaments. Mechanical stimulation (MS) plays an important role in OPLL. DLX5 is an essential tr
Externí odkaz:
https://doaj.org/article/bc7476dfb1e548bbab0b67c215ca7941
Autor:
Frontiers Production Office
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/5e8b888d6d3f499eb1b915ddff85fe4e
Autor:
Arunima Sengupta, Aurélien Dorn, Mohammad Jamshidi, Magali Schwob, Widad Hassan, Lea Lara De Maddalena, Andreas Hugi, Andreas O. Stucki, Patrick Dorn, Thomas M. Marti, Oliver Wisser, Janick D. Stucki, Tobias Krebs, Nina Hobi, Olivier T. Guenat
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Prolonged exposure to environmental respirable toxicants can lead to the development and worsening of severe respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD) and fibrosis. The limited number of FDA-approved inhaled dr
Externí odkaz:
https://doaj.org/article/c791da18c4f74563afefe4f78478af93