Zobrazeno 1 - 10
of 365
pro vyhledávání: '"cyclic AMP (cAMP)"'
Autor:
Susrutha Puthanmadhom Narayanan, Abdalla M. Wedn, Osama Shiraz Shah, Jian Chen, Daniel D. Brown, Priscilla F. McAuliffe, Steffi Oesterreich, Adrian V. Lee
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Objective Invasive lobular breast cancer (ILC) is the most common special type of breast cancer and has unique clinicopathological and molecular hallmarks that differentiate it from the more common invasive carcinoma—no special type (NST).
Externí odkaz:
https://doaj.org/article/c69028712e1246c48c93d4e17467130a
Akademický článek
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Autor:
Marta Sobolczyk, Tomasz Boczek
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
It is commonly accepted that the role of astrocytes exceeds far beyond neuronal scaffold and energy supply. Their unique morphological and functional features have recently brough much attention as it became evident that they play a fundamental role
Externí odkaz:
https://doaj.org/article/feebe4d093664517835ac04f91c72121
Autor:
Enio Setsuo Arakaki Pacini, Naiara Ayako Satori, Edwin Kerry Jackson, Rosely Oliveira Godinho
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Adenosine is a purine nucleoside that, via activation of distinct G protein-coupled receptors, modulates inflammation and immune responses. Under pathological conditions and in response to inflammatory stimuli, extracellular ATP is released from dama
Externí odkaz:
https://doaj.org/article/eb4b9ae440fa407f8ec5a3a108edf206
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Chronic decreases in the second messenger cyclic AMP (cAMP) occur in numerous settings, but how cells compensate for such decreases is unknown. We have used a unique system—murine dendritic cells (DCs) with a DC-selective depletion of the heterotri
Externí odkaz:
https://doaj.org/article/de126dcb359a4e1ba9d7a7370df0e1e0
Publikováno v:
Adipocyte, Vol 9, Iss 1, Pp 427-442 (2020)
Given the high and increasing prevalence of obesity and associated disorders, such as type-2 diabetes, it is important to understand the mechanisms that regulate lipid storage and the differentiation of fat cells, a process termed adipogenesis. Using
Externí odkaz:
https://doaj.org/article/36fa8b73bfba4b438fab7e059f7bc60c
Autor:
Zhiyan Zhou, Ranhui Xi, Jiaxin Liu, Xian Peng, Lei Zhao, Xuedong Zhou, Jiyao Li, Xin Zheng, Xin Xu
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Sustained and non-resolved inflammation is a characteristic of periodontitis. Upon acute inflammation, gingival fibroblasts release cytokines to recruit immune cells to counter environmental stimuli. The intricate regulation of pro-inflammatory signa
Externí odkaz:
https://doaj.org/article/3d8cfe74f4204ca181b58dcb671ef790
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Personized treatment of breast cancer is still a challenge, and more treatment options for breast cancer are warranted. Combination therapies have been a highly appreciated strategy for breast cancer treatment in recent years, and the development of
Externí odkaz:
https://doaj.org/article/5094b02e3f8f43c0b270f738a7bf43fe
Akademický článek
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Publikováno v:
Microbial Cell, Vol 5, Iss 2, Pp 74-87 (2017)
In Salmonella enterica, aminoimidazole carboxamide ribotide (AICAR) is a purine biosynthetic intermediate and a substrate of the AICAR transformylase/IMP cyclohydrolase (PurH) enzyme. When purH is eliminated in an otherwise wild-type strain, AICAR ac
Externí odkaz:
https://doaj.org/article/a9a59423c9d342e99b2b7b11bff0f0e8