Zobrazeno 1 - 10
of 144
pro vyhledávání: '"cuprizone model"'
Akademický článek
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Publikováno v:
Di-san junyi daxue xuebao, Vol 43, Iss 13, Pp 1227-1234 (2021)
Objective To assess the value of combined signal intensity ratio (SIR) and diffusion tensor imaging (DTI) measured at 7.0 T MRI in quantitative detection and analysis of gray and white matter demyelination in the modified cuprizone (CPZ)-induced mous
Externí odkaz:
https://doaj.org/article/f3731a9b81c04257875c6d56d1e7a4dc
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1254 (2023)
The effective treatment of central nervous system (CNS) disorders such as multiple sclerosis (MS) has been challenging due to the limited ability of therapeutic agents to cross the blood–brain barrier (BBB). In this study, we investigated the poten
Externí odkaz:
https://doaj.org/article/3f9385cf3c8f47279743cc689f49e5f8
Autor:
Silvia Marenna, Su-Chun Huang, Gloria Dalla Costa, Raffaele d’Isa, Valerio Castoldi, Elena Rossi, Giancarlo Comi, Letizia Leocani
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The visual system is one of the most accessible routes to study the central nervous system under pathological conditions, such as in multiple sclerosis (MS). Non-invasive visual evoked potential (VEP) and optical coherence tomography (OCT) were used
Externí odkaz:
https://doaj.org/article/92c5b1d8470c42a7b8c0909d277e1e63
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 16182 (2022)
Huperzine A (HupA) is a natural acetylcholinesterase inhibitor (AChEI) with the advantages of high efficiency, selectivity as well as reversibility and can exhibit significant therapeutic effects against certain neurodegenerative diseases. It is also
Externí odkaz:
https://doaj.org/article/af8f3f5eba134a5080f5f9f1241dc29c
Akademický článek
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Autor:
Tengiz Oniani, Laura Vinnenberg, Rahul Chaudhary, Julian A. Schreiber, Kathrin Riske, Brandon Williams, Hans-Christian Pape, John A. White, Anna Junker, Guiscard Seebohm, Sven G. Meuth, Petra Hundehege, Thomas Budde, Mehrnoush Zobeiri
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6285 (2022)
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that is characterized by the progressive loss of oligodendrocytes and myelin and is associated with thalamic dysfunction. Cuprizone (CPZ)-induced general demyelination i
Externí odkaz:
https://doaj.org/article/9fbb2807f42e431c8bf2d65f55c70606
Autor:
Mariela Wittekindt, Hannes Kaddatz, Sarah Joost, Anna Staffeld, Yamen Bitar, Markus Kipp, Linda Frintrop
Publikováno v:
Cells, Vol 11, Iss 11, p 1723 (2022)
Microglia play an important role in the pathology of various central nervous system disorders, including multiple sclerosis (MS). While different methods exist to evaluate the extent of microglia activation, comparative studies investigating the sens
Externí odkaz:
https://doaj.org/article/4710ab7e195b4a428ce566145ed4b392
Akademický článek
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Autor:
David G. Gonsalvez, SangWon Yoo, Jessica L. Fletcher, Rhiannon J. Wood, Georgina A. Craig, Simon S. Murray, Junhua Xiao
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Developing a high-throughput approach to quantify the extent of myelin integrity in preclinical models of demyelinating diseases will enhance our capacity to identify novel therapies for myelin repair. In light of the technical limitations of electro
Externí odkaz:
https://doaj.org/article/bb5142a84d214c319fb21127d07dcb04