Zobrazeno 1 - 10
of 2 479
pro vyhledávání: '"cryo-EM structure"'
Publikováno v:
Prion, Vol 18, Iss 1, Pp 28-39 (2024)
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are multifunctional proteins with integral roles in RNA metabolism and the regulation of alternative splicing. These proteins typically contain prion-like domains of low complexity (PrLDs or LCDs) tha
Externí odkaz:
https://doaj.org/article/5a296812dab845b192abfe0a4c9b32c0
Autor:
Pengfei Fan, Bingjie Sun, Zixuan Liu, Ting Fang, Yi Ren, Xiaofan Zhao, Zhenwei Song, Yilong Yang, Jianmin Li, Changming Yu, Wei Chen
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Orthoebolavirus is a genus of hazardous pathogens that has caused over 30 outbreaks. However, currently approved therapies are limited in scope, as they are only effective against the Ebola virus and lack cross-protection against other orthoebolaviru
Externí odkaz:
https://doaj.org/article/156768d06720445493fc8685108504a1
Autor:
Junping Fan, Chang Guo, Daohong Liao, Han Ke, Jing Lei, Wenjun Xie, Yuliang Tang, Makoto Tominaga, Zhuo Huang, Xiaoguang Lei
Publikováno v:
Advanced Science, Vol 11, Iss 25, Pp n/a-n/a (2024)
Abstract The nonselective calcium‐permeable Transient Receptor Potential Cation Channel Subfamily V Member4 (TRPV4) channel regulates various physiological activities. Dysfunction of TRPV4 is linked to many severe diseases, including edema, pain, g
Externí odkaz:
https://doaj.org/article/2fc8028f0c104a9b845bdd1c9c58a9e8
Autor:
Qingya Shen, Xinyan Tang, Xin Wen, Shizhuo Cheng, Peng Xiao, Shao‐Kun Zang, Dan‐Dan Shen, Lei Jiang, Yanrong Zheng, Huibing Zhang, Haomang Xu, Chunyou Mao, Min Zhang, Weiwei Hu, Jin‐Peng Sun, Yan Zhang, Zhong Chen
Publikováno v:
Advanced Science, Vol 11, Iss 23, Pp n/a-n/a (2024)
Abstract G‐protein‐coupled receptors (GPCRs) transmit downstream signals predominantly via G‐protein pathways. However, the conformational basis of selective coupling of primary G‐protein remains elusive. Histamine receptors H2R and H3R coupl
Externí odkaz:
https://doaj.org/article/8143a64c78c74d9eab3c2726cae8a215
Autor:
Qin Hong, Shuxia Wang, Xiaoli Wang, Wenyu Han, Tian Chen, Yan Liu, Fei Cheng, Song Qin, Shengtao Zhao, Qingwei Liu, Yao Cong, Zhong Huang
Publikováno v:
Vaccines, Vol 12, Iss 9, p 1077 (2024)
Poliovirus (PV) is on the brink of eradication due to global vaccination programs utilizing live-attenuated oral and inactivated polio vaccines. Recombinant PV virus-like particles (VLPs) are emerging as a safe next-generation vaccine candidate for t
Externí odkaz:
https://doaj.org/article/4d76dd154be54005ab3d7d59f5ef5275
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 55, Pp 1551-1560 (2023)
Microtubules are hollow α/β-tubulin heterodimeric polymers that play critical roles in cells. In vertebrates, both α- and β-tubulins have multiple isotypes encoded by different genes, which are intrinsic factors in regulating microtubule function
Externí odkaz:
https://doaj.org/article/171d7d53ad884bb5b54ae004de057bd0
Autor:
Theresa Gewering, Deepali Waghray, Kristian Parey, Hendrik Jung, Nghi NB Tran, Joel Zapata, Pengyi Zhao, Hao Chen, Dovile Januliene, Gerhard Hummer, Ina Urbatsch, Arne Moeller, Qinghai Zhang
Publikováno v:
eLife, Vol 12 (2024)
P-glycoprotein (Pgp) is a prototypical ATP-binding cassette (ABC) transporter of great biological and clinical significance.Pgp confers cancer multidrug resistance and mediates the bioavailability and pharmacokinetics of many drugs (Juliano and Ling,
Externí odkaz:
https://doaj.org/article/7fa28e67501440539767d8acba59a675
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Zhengshan Hu, Jian Yang
Publikováno v:
Channels, Vol 17, Iss 1 (2023)
ABSTRACTRecent years have seen an outpouring of atomic or near atomic resolution structures of cyclic nucleotide-gated (CNG) channels, captured in closed, transition, pre-open, partially open, and fully open states. These structures provide unprecede
Externí odkaz:
https://doaj.org/article/480c1964004544d8a1798beb66b11daf
Autor:
Tiantian Xu, Lu Zhang
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4385-4394 (2023)
Since the outbreak of the COVID-19 pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) has become a main target for antiviral therapeutics due to its essential role in viral replication and trans
Externí odkaz:
https://doaj.org/article/650b02dd63e84959a05b12fd278e5b9d