Zobrazeno 1 - 10
of 9 613
pro vyhledávání: '"cryo‐electron microscopy"'
Publikováno v:
Lyotropic Liquid Crystals.
Externí odkaz:
https://doi.org/10.1093/9780191924927.003.0003
Autor:
Ana Parra, Isabel Barranco, Pablo Martínez-Díaz, Esperanza González, Oihane E. Albóniga, Diana Cabrera, Juan M. Falcón-Pérez, Jordi Roca
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Seminal plasma (SP) is rich in extracellular vesicles (EVs), which are still poorly studied, especially in livestock species. To better understand their functional role in both spermatozoa and endometrial epithelial cells, proper characteriz
Externí odkaz:
https://doaj.org/article/b471ea28503441b88df4fa767e398f4a
Autor:
Evgeny B. Pichkur, Mikhail F. Vorovitch, Alla L. Ivanova, Elena V. Protopopova, Valery B. Loktev, Dmitry I. Osolodkin, Aydar A. Ishmukhametov, Valeriya R. Samygina
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTTick-borne encephalitis virus (TBEV) causes a severe disease, tick-borne encephalitis (TBE), that has a substantial epidemiological importance for Northern Eurasia. Between 10,000 and 15,000 TBE cases are registered annually despite the avail
Externí odkaz:
https://doaj.org/article/c8c766a04fd34eb5b0173f8e54e4a91d
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
ABSTRACTLow molecular weight proteins and protein assemblies can now be investigated using cryo-electron microscopy (EM) as a complement to traditional structural biology techniques. It is important, however, to not lose sight of the dynamic informat
Externí odkaz:
https://doaj.org/article/cefba15d3c474cc494a294cfb295b6f1
Publikováno v:
mLife, Vol 3, Iss 2, Pp 240-250 (2024)
Abstract Cytidine triphosphate synthase (CTPS) plays a pivotal role in the de novo synthesis of cytidine triphosphate (CTP), a fundamental building block for RNA and DNA that is essential for life. CTPS is capable of directly binding to all four nucl
Externí odkaz:
https://doaj.org/article/24b3fd2b11c24a5082fd27ce6a4462d2
Autor:
Ujjayini Ghosh, Eric Tse, Hyunjun Yang, Marie Shi, Christoffer D. Caro, Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth, Carlo Condello
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract Down syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among their complex clinical features, including musculoskeletal, neurological, and cardiovascular disabilities, individuals with DS have an increased risk
Externí odkaz:
https://doaj.org/article/aac87a63fb79463b9e1a637cad62d4a9
Autor:
Hayeon Lee, Yeseul Lee, Jinseok Lee, Hyeongseop Jeong, Dong Keon Yon, Clarissa L. Durie, Bumhan Ryu, Jeong Min Chung
Publikováno v:
Journal of Analytical Science and Technology, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The selection of defocus ranges for small datasets in cryo-electron microscopy (cryo-EM) is under-researched. We present a comprehensive benchmark experiment that aimed to evaluate the relationship between contrast, defocus, and resolution,
Externí odkaz:
https://doaj.org/article/6bdbe9f1c3fe4669a5e6f379eaa933a1
Autor:
Oliver Debski-Antoniak, Alex Flynn, David P. Klebl, Moisés H. Rojas Rechy, Christian Tiede, Ian A. Wilson, Stephen P. Muench, Darren Tomlinson, Juan Fontana
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Influenza A virus (IAV) is well known for its pandemic potential. While current surveillance and vaccination strategies are highly effective, therapeutic approaches are often short-lived due to the high mutation rates of IAV. Recently, monoc
Externí odkaz:
https://doaj.org/article/988bf05e653249ae9274081613bd91c1
Publikováno v:
eLife, Vol 13 (2024)
The CALHM proteins constitute a family of large pore channels that contains six closely related paralogs in humans. Two family members, CALHM1 and 3, have been associated with the release of ATP during taste sensation. Both proteins form heteromeric
Externí odkaz:
https://doaj.org/article/6bc97a40a55242dba1f967de43737d14
Autor:
Tianxin Wang, Wenqin Tang, Ziyi Zhao, Ran Zhao, Zhenyu Lv, Xuzhen Guo, Quanchang Gu, Boxiang Liu, Haoyu Lv, Jiayan Chen, Kaiquan Zhang, Fahui Li, Jiangyun Wang
Publikováno v:
Advanced Science, Vol 11, Iss 14, Pp n/a-n/a (2024)
Abstract The G‐protein‐coupled human cannabinoid receptor 1 (CB1) is a promising therapeutic target for pain management, inflammation, obesity, and substance abuse disorders. The structures of CB1‐Gi complexes in synthetic agonist‐bound forms
Externí odkaz:
https://doaj.org/article/30365fbeb6904c4dad4d657e84dc1973