Výsledky vyhledávání - "covalent flavinylation"

Metabolic selection of a homologous recombination-mediated gene loss protects Trypanosoma brucei from ROS production by glycosomal fumarate reductase

Autor: Wargnies, Marion, Plazolles, Nicolas, Schenk, Robin, Villafraz, Oriana, Dupuy, Jean-William, Biran, Marc, Bachmaier, Sabine, Baudouin, Hélène, Clayton, Christine, Boshart, Michael, Bringaud, Frédéric

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 296, pp.100548. ⟨10.1016/j.jbc.2021.100548⟩
The Journal of Biological Chemistry

International audience; The genome of trypanosomatids rearranges by using repeated sequences as platforms for amplification or deletion of genomic segments. These stochastic recombination events have a direct impact on gene dosage and foster the sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::432b54ef02595b3c3feb09753cee04e9
https://hal.archives-ouvertes.fr/hal-03216701

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Vanillyl alcohol oxidase

Autor: Ewing, Tom A, Gygli, Gudrun, Fraaije, Marco W, van Berkel, Willem J H, Chaiyen, Pimchai, Tamanoi, Fuyuhiko

Publikováno v: Flavin-Dependent Enzymes: Mechanisms, Structures and Applications, 47, 87-116
Enzymes. Academic Press
Enzymes
Flavin-Dependent Enzymes: Mechanisms, Structures and Applications ISBN: 9780128201374

This review presents a historical outline of the research on vanillyl alcohol oxidase (VAO) from Penicillium simplicissimum, one of the canonical members of the VAO/PCMH flavoprotein family. After describing its discovery and initial biochemical char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a570eec5dc1c9caf402dc810aef21adb
https://research.rug.nl/en/publications/d3f3464f-6015-4b0d-af84-fe6a801b2fe9

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Expanding the Repertoire of Flavoenzyme-Based Biocatalysis

Autor: Andrea Mattevi, Quoc Nguyen, Marco W. Fraaije

Publikováno v: Future Directions in Biocatalysis: Second Edition, 119-133
ISSUE=2nd;STARTPAGE=119;ENDPAGE=133;TITLE=Future Directions in Biocatalysis

The flavin tricyclic conjugated isoalloxazine ring system can undoubtedly be recognized as one of the most versatile cofactor types. Flavin-dependent enzymes display a remarkable wide range of chemical reactions which involve both one- and two-electr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b39ec6a6ed82748e4a246dd3e6eec4
https://research.rug.nl/en/publications/0309865b-1463-4503-aa11-a95b7ca182dc

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Agaricus meleagris pyranose dehydrogenase: Influence of covalent FAD linkage on catalysis and stability

Autor: Krondorfer, Iris, Brugger, Dagmar, Paukner, Regina, Scheiblbrandner, Stefan, Pirker, Katharina F., Hofbauer, Stefan, Furtmüller, Paul G., Obinger, Christian, Haltrich, Dietmar, Peterbauer, Clemens K.

Publikováno v: Archives of Biochemistry and Biophysics

Highlights • The mutation H103Y slowed down the reductive half-reaction by three orders of magnitude. • Secondary structure composition was not altered according to CD spectra. • EPR spectroscopy identified a semiquinone radical in the wild-typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2d1418868ea8de33a6fb84c759ad6bc4
http://europepmc.org/articles/PMC4148704

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What's in a covalent bond? On the role and formation of covalently bound flavin cofactors

Publikováno v: Febs Journal. 276(13):3405-3427

Many enzymes use one or more cofactors, such as biotin, heme, or flavin. These cofactors may be bound to the enzyme in a noncovalent or covalent manner. Although most flavoproteins contain a noncovalently bound flavin cofactor (FMN or FAD), a large n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::0017ad1d672e5cc17b534d6a0f425fce
https://doi.org/10.1111/j.1742-4658.2009.07053.x

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Covalent flavinylation of vanillyl-alcohol oxidase is an autocatalytic process

Publikováno v: Febs Journal. 275(20):5191-5200

Vanillyl-alcohol oxidase (VAO; EC 1.1.3.38) contains a covalently 8 alpha-histidyl bound FAD, which represents the most frequently encountered covalent flavin-protein linkage. To elucidate the mechanism by which VAO covalently incorporates the FAD co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___00893::05789e5db42d1b05d9ef895552ff3e00
https://doi.org/10.1111/j.1742-4658.2008.06649.x

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Discovery of a eugenol oxidase from Rhodococcus sp strain RHA1

Publikováno v: Febs Journal. 274(9):2311-2321

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___00893::d8c6ea980d909b2b5f4eaec85a2462c5
https://hdl.handle.net/11370/1bbe364a-c744-48d8-91c9-c317e30e757c

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What's in a covalent bond? On the role and formation of covalently bound flavin cofactors

Autor: William S. McIntire, Nigel S. Scrutton, Marco W. Fraaije, Dominic P. H. M. Heuts

Publikováno v: The FEBS journal. 276(13)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3bad1a2448ef74019e7688e2ae4ce77
https://pubmed.ncbi.nlm.nih.gov/19438712

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