Zobrazeno 1 - 10
of 1 534
pro vyhledávání: '"copy number alteration"'
Autor:
Felipe Luz Torres Silva, Mayara Ferreira Euzébio, Juliana Silveira Ruas, Mayra Troiani Franco, Alejandro Enzo Cassone, Thais Junqueira, Danielle Ribeiro Lucon, Izilda Aparecida Cardinalli, Luis Henrique Pereira, Priscila Pini Zenatti, Patricia Yoshioka Jotta, Mariana Maschietto
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Pediatric sarcomas present heterogeneous morphology, genetics and clinical behavior posing a challenge for an accurate diagnosis. DNA methylation is an epigenetic modification that coordinates chromatin structure and regulates gene expressio
Externí odkaz:
https://doaj.org/article/cccf1954e3c14402a2fad4dd095233ca
Autor:
François Bertucci, Arnaud Guille, Florence Lerebours, Michele Ceccarelli, Najeeb Syed, José Adélaïde, Pascal Finetti, Naoto T. Ueno, Steven Van Laere, Patrice Viens, Alexandre De Nonneville, Anthony Goncalves, Daniel Birnbaum, Céline Callens, Davide Bedognetti, Emilie Mamessier
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Neoadjuvant chemotherapy (NACT) became a standard treatment strategy for patients with inflammatory breast cancer (IBC) because of high disease aggressiveness. However, given the heterogeneity of IBC, no molecular feature reliably
Externí odkaz:
https://doaj.org/article/1068ae1848944ff180c01ffd49e76be5
Autor:
João Figueira Scarini, Wellington Lima Sabino, Reydson Alcides de Lima-Souza, Erika Said Abu Egal, Alfio José Tincani, Rogério Gondak, Luiz Paulo Kowalski, Ana Cristina Victorino Krepischi, Albina Altemani, Fernanda Viviane Mariano
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The mechanisms involved with the pathogenesis of carcinoma ex pleomorphic adenoma (CXPA) seem to be associated with the accumulation of molecular alterations in the pleomorphic adenoma (PA). In this sense, using array-based comparative genom
Externí odkaz:
https://doaj.org/article/9fecbf6d187a46cfb30afe45b209fe40
Autor:
Marie-Lucie Racu, Andrea Alex Schiavo, Claude Van Campenhout, Nancy De Nève, Thomas Masuy, Calliope Maris, Christine Decaestecker, Myriam Remmelink, Isabelle Salmon, Nicky D'Haene
Publikováno v:
Experimental and Molecular Pathology, Vol 139, Iss , Pp 104920- (2024)
Pancreatic ductal adenocarcinoma (PDAC) is reported to be amongst the cancers with the lowest survival rate at 5 years. In the present study we aimed to validate a targeted next-generation sequencing (tNGS) panel to use in clinical routine, investiga
Externí odkaz:
https://doaj.org/article/60caf256d47f4ab1a2308a8d5e394c37
Autor:
François Bertucci, Florence Lerebours, Michele Ceccarelli, Arnaud Guille, Najeeb Syed, Pascal Finetti, José Adélaïde, Steven Van Laere, Anthony Goncalves, Patrice Viens, Daniel Birnbaum, Emilie Mamessier, Céline Callens, Davide Bedognetti
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Inflammatory breast cancer (IBC) is the most pro-metastatic form of BC. Better understanding of its enigmatic pathophysiology is crucial. We report here the largest whole-exome sequencing (WES) study of clinical IBC samples. Metho
Externí odkaz:
https://doaj.org/article/d411209f682649f3b4011eb089a7cbba
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background Copy number alteration (CNA) is one of the major genomic variations that frequently occur in cancers, and accurate inference of CNAs is essential for unmasking intra-tumor heterogeneity (ITH) and tumor evolutionary history. Single
Externí odkaz:
https://doaj.org/article/12d12acf9dce4c609e1fa19c9c6a61c9
Autor:
Yoshihiko Koike, Mitsumasa Osakabe, Ryo Sugimoto, Noriyuku Uesugi, Takayuki Matsumoto, Hiromu Suzuki, Naoki Yanagawa, Tamotsu Sugai
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 2, Pp n/a-n/a (2024)
Abstract We performed comprehensive analyses of somatic copy number alterations (SCNAs) and gene expression profiles of gastric intramucosal neoplasia (IMN) using array‐based methods in 97 intestinal‐type IMNs, including 39 low‐grade dysplasias
Externí odkaz:
https://doaj.org/article/e091adcb3e1c43f9a09f4e67fa5378cc
Autor:
Renjie Dou, Shaobo Kang, Huan Yang, Wanmei Zhang, Yijing Zhang, Yuanyuan Liu, Yanyan Ping, Bo Pang
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-15 (2023)
Abstract Background MicroRNAs (miRNAs) play critical roles in cancer initiation and progression, which were critical components to maintain the dynamic balance of competing endogenous RNA (ceRNA) networks. Somatic copy number alterations (SCNAs) in t
Externí odkaz:
https://doaj.org/article/342f01ea917d4ce9b8708ef8583e9108
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-28 (2023)
Abstract Phylogenetic trees based on copy number profiles from multiple samples of a patient are helpful to understand cancer evolution. Here, we develop a new maximum likelihood method, CNETML, to infer phylogenies from such data. CNETML is the firs
Externí odkaz:
https://doaj.org/article/5e78e58832ea49fca3b1f1cb351c076f
Publikováno v:
BJUI Compass, Vol 4, Iss 3, Pp 256-265 (2023)
Abstract Background Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer. We performed a systematic review and meta‐analysis to evaluate the prevalence of genomic alterations in NEPC and better understand its molecular featu
Externí odkaz:
https://doaj.org/article/6ad763676f84450aa2fdd56f3a854174