Zobrazeno 1 - 10
of 460
pro vyhledávání: '"copy number aberration"'
Autor:
Yu Chang, Shiyong Li, Zhiming Li, Xinhua Wang, Fangyuan Chang, Shuaipeng Geng, Dandan Zhu, Guolin Zhong, Wei Wu, Yinyin Chang, Shichun Tu, Mao Mao
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundAccording to GLOBOCAN 2020, lymphoma ranked as the 9th most common cancer and the 12th leading cause of cancer-related deaths worldwide. Traditional diagnostic methods rely on the invasive excisional lymph node biopsy, which is an invasive
Externí odkaz:
https://doaj.org/article/7b1163ea250141adb6fc9e1021209686
Publikováno v:
PeerJ, Vol 11, p e15244 (2023)
Genomic instability is an important hallmark of cancer and more recently has been identified in others like neurodegenrative diseases. Chromosomal instability, as a measure of genomic instability, has been used to characterize clinical and biological
Externí odkaz:
https://doaj.org/article/2b7bda82b19e4b839625dc19ae09106b
Autor:
Hillary P. Esplen, Richard K. Yang, Awdhesh Kalia, Zhenya Tang, Guilin Tang, L. Jeffrey Medeiros, Gokce A. Toruner
Publikováno v:
Life, Vol 13, Iss 11, p 2192 (2023)
Somatic copy number alterations (SCNAs) are frequently observed in high-grade ovarian serous carcinoma (HGOSC). However, their impact on gene expression levels has not been systematically assessed. In this study, we explored the relationship between
Externí odkaz:
https://doaj.org/article/fe3c79afa18c4b5bb608791eddb0b584
Autor:
Qingyao Huang, Michael Baudis
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Genome variation is the direct cause of cancer and driver of its clonal evolution. While the impact of many point mutations can be evaluated through their modification of individual genomic elements, even a single copy number aberration (CNA) may enc
Externí odkaz:
https://doaj.org/article/6c6aa5fcade8459e887032dea617b511
Akademický článek
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Autor:
Beatriz Fernández-Blanco, Ana Pilar Berbegall, Susana Martin-Vañó, Victoria Castel, Samuel Navarro, Rosa Noguera
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 12-20 (2021)
Survival in high-risk neuroblastoma (HR-NB) patients remains poor despite multimodal treatment. We aimed to identify HR-NB patients with worse outcomes by analyzing the genomic instability derived from segmental chromosomal aberrations. We calculated
Externí odkaz:
https://doaj.org/article/e593a4ff1c934b3792a8b1d86f015b8b
Autor:
Anand Khadse, Vilde D. Haakensen, Laxmi Silwal-Pandit, Julian Hamfjord, Patrick Micke, Johan Botling, Odd Terje Brustugun, Ole Christian Lingjærde, Åslaug Helland, Elin H. Kure
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Lung cancer is a common disease with a poor prognosis. Genomic alterations involving the KRAS gene are common in lung carcinomas, although much is unknown about how different mutations, deletions, and expressions influence the disease course. The fir
Externí odkaz:
https://doaj.org/article/add8e489bc4c4fa9b31afcd0d783f3bf
Autor:
N. V. Litviakov, M. K. Ibragimova, M. M. Tsyganov, I. V. Deriusheva, A. M. Pevsner, E. Yu. Garbukov, A. V. Doroshenko, E. M. Slonimskaya
Publikováno v:
Сибирский онкологический журнал, Vol 19, Iss 3, Pp 78-88 (2020)
We studied the association between the presence of 2 or more stemness gene amplifications as well as copy number aberrations (CNAs) of WNT signaling genes in residual breast tumor and metastasis. WNT pathway genes associated with metastasis were iden
Externí odkaz:
https://doaj.org/article/8473fb2cc16145229abb085a77755e67
Autor:
Haoren Wang, Shizhe Yu, Qiang Cai, Duo Ma, Lingpeng Yang, Jian Zhao, Long Jiang, Xinyi Zhang, Zhiyong Yu
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, and heterogeneity of HCC is the major barrier in improving patient outcome. To stratify HCC patients with different degrees of malignancy and provide preci
Externí odkaz:
https://doaj.org/article/37771dc90fd6475589007c6b3f49d831
Publikováno v:
Algorithms for Molecular Biology, Vol 14, Iss 1, Pp 1-14 (2019)
Abstract Background Tumors exhibit extensive intra-tumor heterogeneity, the presence of groups of cellular populations with distinct sets of somatic mutations. This heterogeneity is the result of an evolutionary process, described by a phylogenetic t
Externí odkaz:
https://doaj.org/article/33dbc9a41bc2435491d25e18f2a221c5