Výsledky vyhledávání - "convallatoxin"

Akademický článek

Development and Validation of an Analytical Procedure for Determining Convallatoxin in Medicinal Products Containing Cardiac Glycosides of Lily of the Valley

Autor: T. A. Golomazova, N. P. Antonova, N. E. Semenova, E. P. Shefer, S. S. Prokhvatilova

Publikováno v: Регуляторные исследования и экспертиза лекарственных средств, Vol 14, Iss 5, Pp 580-589 (2024)

INTRODUCTION. The safe use of lily-of-the-valley medicinal products requires adequately controlling the content of cardiac glycosides. The State Pharmacopoeia of the Russian Federation stipulates that the content of cardiac glycosides in lily-of-the-

Externí odkaz: https://doaj.org/article/e3db2c025810466d8a427c489d9529e7

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Akademický článek

Convallatoxin, the primary cardiac glycoside in lily of the valley (Convallaria majalis), induces tissue factor expression in endothelial cells

Autor: Mami Morimoto, Kohei Tatsumi, Katsuya Yuui, Ikuko Terazawa, Risa Kudo, Shogo Kasuda

Publikováno v: Veterinary Medicine and Science, Vol 7, Iss 6, Pp 2440-2444 (2021)

Abstract Background Convallotoxin (CNT), present in lily of the valley (Convallaria majalis), is a toxin that causes food poisoning among humans and companion animals. Although various symptoms of CNT poisoning have been well described, hypercoagulab

Externí odkaz: https://doaj.org/article/1b560d0716e6410eaa6fb0f2a8d4a436

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Convallatoxin Promotes M2 Macrophage Polarization to Attenuate Atherosclerosis Through PPARγ-Integrin αvβ5 Signaling Pathway

Autor: Zhang Y, Shi X, Han J, Peng W, Fang Z, Zhou Y, Xu X, Lin J, Xiao F, Zhao L, Lin Y

Publikováno v: Drug Design, Development and Therapy, Vol Volume 15, Pp 803-812 (2021)

Yi Zhang,1 Xiujin Shi,1 Jialun Han,1 Wenxing Peng,1 Zhenwei Fang,1 Yang Zhou,1 Xiaoyu Xu,1 Jie Lin,2,3 Fucheng Xiao,4 Limin Zhao,3 Yang Lin1 1Department of Pharmacy, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, People’s Rep

Externí odkaz: https://doaj.org/article/cdf39b1fb5f1474dbd563564c5c59adf

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Akademický článek

The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner

Autor: Sarah E. Anderson, Christopher E. Barton

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 13, Iss C, Pp 42-45 (2017)

Cardiac glycosides are plant-derived molecules that have shown antiproliferative properties against cancer cells, though the mechanism of action is not completely understood. We show that one cardiac glycoside, convallatoxin, presents antiproliferati

Externí odkaz: https://doaj.org/article/87ce8acb3465477082e32722e3d860cd

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Convallatoxin inhibits IL‐1β production by suppressing zinc finger protein 91 (ZFP91)‐mediated pro‐IL‐1β ubiquitination and caspase‐8 inflammasome activity

Autor: Yue Xing, Hong Xiang Zuo, Ming Yue Li, Zhi Hong Zhang, Juan Ma, Xuejun Jin, Jing Ying Wang, Hong Lan Jin

Publikováno v: British Journal of Pharmacology. 179:1887-1907

ZFP91 positively regulates IL-1β production in macrophages and may be a potential therapeutic target to treat inflammatory-related diseases. We investigated whether this process is modulated by convallatoxin, which is a cardiac glycoside isolated fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b1b2ac4fa908b1e791808135d446c8
https://doi.org/10.1111/bph.15758

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Convallatoxin Promotes M2 Macrophage Polarization to Attenuate Atherosclerosis Through PPARγ-Integrin αvβ5 Signaling Pathway

Autor: Yi Zhang, Yang Zhou, Wenxing Peng, Xiaoyu Xu, Zhenwei Fang, Yang Lin, Fucheng Xiao, Xiujin Shi, Jialun Han, Limin Zhao, Jie Lin

Publikováno v: Drug Design, Development and Therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a50f46bead7283ab4a7c727efca2a5
https://doi.org/10.2147/dddt.s288728

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Phytochemicals, antioxidants, estimation of cardiac glycoside (Scillaren A) and detection of major metabolites using LC-MS from Drimia species

Autor: Manoj M. Lekhak, U.M. Lekhak, P. B. Yadav, S. G. Ghane

Publikováno v: South African Journal of Botany. 140:259-268

Drimia Jacq., a bulbous geophyte belonging to family Hyacinthaceae Batsch ex Borkh. is well known for its medicinal values. Leaves and bulbs of eight genotypes of Drimia were sequentially extracted with three solvents (DCM, MeOH and H2O) and analysed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e26f54393fb463ac7929c09ecf523a1d
https://doi.org/10.1016/j.sajb.2020.05.002

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Regulation of NRF2 by Na+/K+-ATPase: implication of tyrosine phosphorylation of Src

Autor: Le Ba Nam, Young-Sam Keum

Publikováno v: Free Radical Research. 54:883-893

Tumors adapt well to the imbalanced redox status created by rapid growth and limited nutrient availability because they highly express high levels of NRF2 to counteract oxidative stress. Therefore, inhibition of NRF2 is currently considered a feasibl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32f890db6bf39c9bb18cb25f20511db3
https://doi.org/10.1080/10715762.2020.1735633

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