Next-generation 3D printed multipurpose prevention intravaginal ring for prevention of HIV, HSV-2, and unintended pregnancy.

Autor: Dahl DK; Joint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Srinivasan P; Laboratory Branch, Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Janusziewicz R; Joint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., King JL; Joint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Shrivastava R; Joint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Zhang J; Laboratory Branch, Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Little D; Katmai Government Services (KGS), Anchorage, AK, USA., Bachman S; 4ES Corporation, San Antonio, TX, USA., Kelley K; Honnête, LLC, Atlanta, GA, United States of America., Cottrell ML; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Schauer AP; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Sykes C; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kashuba ADM; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Smith J; Laboratory Branch, Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: ajo9@cdc.gov., Benhabbour SR; Joint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: benhabs@email.unc.edu.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Dec; Vol. 376, pp. 1209-1224. Date of Electronic Publication: 2024 Nov 12.

Leveraging international stakeholders' experiences with oral PrEP costs to accelerate implementation of the monthly dapivirine vaginal ring: A qualitative study.

Autor: Heck CJ; Department of Epidemiology, Columbia University Mailman School of Public Health, 622 West 168th Street, 8th Floor, New York, NY, 10032, United States of America. cjh2204@cumc.columbia.edu.; Division of Infectious Diseases, Columbia University Irving Medical Center, 622 West 168th Street, 8th Floor, New York, NY, 10032, United States of America. cjh2204@cumc.columbia.edu., Kripke K; Avenir Health, Takoma Park, MD, United States of America., Dam A; United States Agency for International Development, Washington, DC, United States of America., Torres-Rueda S; The London School of Hygiene and Tropical Medicine, London, United Kingdom., Bozzani F; The London School of Hygiene and Tropical Medicine, London, United Kingdom., Obermeyer C; The Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland., Yohannes K; University of Virginia School of Medicine, Charlottesville, VA, United States of America., Deacon J; The CDC Foundation, Atlanta, GA, United States of America., Meyers K; Division of Infectious Diseases, Columbia University Irving Medical Center, 622 West 168th Street, 8th Floor, New York, NY, 10032, United States of America.; The Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY, United States of America., Quigee D; Division of Infectious Diseases, Columbia University Irving Medical Center, 622 West 168th Street, 8th Floor, New York, NY, 10032, United States of America., Wiant S; Division of Infectious Diseases, Columbia University Irving Medical Center, 622 West 168th Street, 8th Floor, New York, NY, 10032, United States of America., Forsythe S; Avenir Health, Glastonbury, CT, United States of America., Malati C; United States Agency for International Development, Washington, DC, United States of America., Larson M; FHI 360, Durham, NC, United States of America., Sobieszczyk ME; Division of Infectious Diseases, Columbia University Irving Medical Center, 622 West 168th Street, 8th Floor, New York, NY, 10032, United States of America., Castor D; Department of Epidemiology, Columbia University Mailman School of Public Health, 622 West 168th Street, 8th Floor, New York, NY, 10032, United States of America. dc2022@cumc.columbia.edu.; Division of Infectious Diseases, Columbia University Irving Medical Center, 622 West 168th Street, 8th Floor, New York, NY, 10032, United States of America. dc2022@cumc.columbia.edu.

Publikováno v: Health research policy and systems [Health Res Policy Syst] 2024 Nov 25; Vol. 22 (1), pp. 156. Date of Electronic Publication: 2024 Nov 25.

Efficacy of the Dapivirine Vaginal Ring Accounting for Imperfect Adherence.

Autor: Husnik MJ; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Heffron R; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Hughes JP; Department of Biostatistics, University of Washington, Seattle, WA, USA., Richardson B; Department of Biostatistics, University of Washington, Seattle, WA, USA., van der Straten A; Department of Medicine, The Center for AIDS Prevention Studies, University of California San Francisco, San Francisco, CA, USA.; ASTRA Consulting, Kensington, CA, USA., Palanee-Phillips T; Faculty of Health Sciences, Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa., Soto-Torres L; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Singh D; University of Pittsburgh, Pittsburgh, PA, USA.; Magee-Womens Research Institute, Pittsburgh, PA, USA., Mirembe BG; Makerere University John Hopkins University Research Collaboration (MU-JHU), Kampala, Uganda., Livant E; Magee-Womens Research Institute, Pittsburgh, PA, USA., Gaffoor Z; HIV Prevention Research Unit, South African Medical Research Council, Cape Town, South Africa., Mansoor LE; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa., Siva SS; HIV Prevention Research Unit, South African Medical Research Council, Cape Town, South Africa., Dadabhai S; Johns Hopkins Bloomberg School of Public Health, Blantyre, Malawi., Kiweewa FM; Makerere University John Hopkins University Research Collaboration (MU-JHU), Kampala, Uganda., Baeten JM; Department of Epidemiology, University of Washington, Seattle, WA, USA. jbaeten@uw.edu.; Department of Global Health, University of Washington, Seattle, WA, USA. jbaeten@uw.edu.

Publikováno v: AIDS and behavior [AIDS Behav] 2024 Nov; Vol. 28 (11), pp. 3873-3882. Date of Electronic Publication: 2024 Aug 19.

Depression Among Pregnant and Breastfeeding Persons Participating in Two Randomized Trials of the Dapivirine Vaginal Ring and Oral Pre-Exposure Prophylaxis (PrEP) in Malawi, South Africa, Uganda, and Zimbabwe.

Autor: Stoner MCD; RTI International, Berkeley, CA, USA. mcstoner@rti.org., Mathebula F; Wits RHI, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Sedze N; Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe., Seyama L; Johns Hopkins Project, Kamuzu University of Health Sciences, Blantyre, Malawi., Mohuba R; Wits RHI, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Fabiano Z; Johns Hopkins Project, Kamuzu University of Health Sciences, Blantyre, Malawi., Etima J; Makerere University - Johns Hopkins University (MU-JHU) Research Collaboration, Kampala, Uganda., Young A; RTI International, Berkeley, CA, USA., Scheckter R; FHI 360, Durham , NC, USA., van der Straten A; ASTRA Consulting, Berkeley, CA, USA., Piper J; National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, USA., Noguchi L; Division of Reproductive, Maternal, Newborn, Child and Adolescent Health, Jhpiego/Johns Hopkins University, Washington, DC, USA., Montgomery ET; RTI International, Berkeley, CA, USA., Balán IC; Florida State University College of Medicine, Tallahassee, FL, USA.

Publikováno v: AIDS and behavior [AIDS Behav] 2024 Jul; Vol. 28 (7), pp. 2264-2275. Date of Electronic Publication: 2024 Mar 25.

Development and verification of mechanistic vaginal absorption and metabolism model to predict systemic exposure after vaginal ring and gel application.

Autor: Thakur K; Simcyp Division, Certara UK Limited, Sheffield, UK., Telaprolu KC; Simcyp Division, Certara UK Limited, Sheffield, UK., Paterson D; Simcyp Division, Certara UK Limited, Sheffield, UK., Salem F; Simcyp Division, Certara UK Limited, Sheffield, UK.; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, R&D, Stevenage, UK., Arora S; Simcyp Division, Certara UK Limited, Sheffield, UK.; Janssen Pharmaceutical, Companies of Johnson & Johnson, Beerse, Belgium., Polak S; Simcyp Division, Certara UK Limited, Sheffield, UK.; Chair of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2024 Jun; Vol. 90 (6), pp. 1428-1449. Date of Electronic Publication: 2024 Mar 07.