Zobrazeno 1 - 10
of 180
pro vyhledávání: '"constraint-based model"'
Autor:
Ke‐Lin Chen, Feng‐Sheng Wang
Publikováno v:
FEBS Open Bio, Vol 13, Iss 12, Pp 2172-2186 (2023)
Computational systems biology plays a key role in the discovery of suitable antiviral targets. We designed a cell‐specific, constraint‐based modeling technique for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐infected lungs.
Externí odkaz:
https://doaj.org/article/655e3403b310476dab208345dbad27cd
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 602 (2024)
Nicotinamide adenine dinucleotide (NAD) is a ubiquitous molecule found within all cells, acting as a crucial coenzyme in numerous metabolic reactions. It plays a vital role in energy metabolism, cellular signaling, and DNA repair. Notably, NAD levels
Externí odkaz:
https://doaj.org/article/9ce9094a232146be9311a31c9e21b3e2
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-7 (2020)
Abstract Background Constraint-based metabolic modeling has been applied to understand metabolism related disease mechanisms, to predict potential new drug targets and anti-metabolites, and to identify biomarkers of complex diseases. Although the sta
Externí odkaz:
https://doaj.org/article/4f5c4bd877d94e75932160cf465a614c
Autor:
Anatoly Sorokin, Igor Goryanin
Publikováno v:
Biomolecules, Vol 13, Iss 3, p 500 (2023)
Background: Whole-genome models (GEMs) have become a versatile tool for systems biology, biotechnology, and medicine. GEMs created by automatic and semi-automatic approaches contain a lot of redundant reactions. At the same time, the nonlinearity of
Externí odkaz:
https://doaj.org/article/621d490216084c42b7fad2e778c9f3ea
Akademický článek
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Autor:
Yier Ma, Takeyuki Tamura
Publikováno v:
Frontiers in Bioinformatics, Vol 1 (2021)
Flux balance analysis (FBA) is a crucial method to analyze large-scale constraint-based metabolic networks and computing design strategies for strain production in metabolic engineering. However, as it is often non-straightforward to obtain such desi
Externí odkaz:
https://doaj.org/article/a49b01024d494f22b434ae13ef59627b
Autor:
Han Yu, Rachael Hageman Blair
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Mathematical models of biological networks can provide important predictions and insights into complex disease. Constraint-based models of cellular metabolism and probabilistic models of gene regulatory networks are two distinct a
Externí odkaz:
https://doaj.org/article/95b5116359304e2bafe6652c72484298
Autor:
Ulf W. Liebal, Lena Ullmann, Christian Lieven, Philipp Kohl, Daniel Wibberg, Thiemo Zambanini, Lars M. Blank
Publikováno v:
Journal of Fungi, Vol 8, Iss 5, p 524 (2022)
Ustilago maydis is an important plant pathogen that causes corn smut disease and serves as an effective biotechnological production host. The lack of a comprehensive metabolic overview hinders a full understanding of the organism’s environmental ad
Externí odkaz:
https://doaj.org/article/99dfc86221ba4406bd3632d82e928773
Publikováno v:
Sentence Processing: A Crosslinguistic Perspective. :211-225
Autor:
Jared T. Broddrick, Richard Szubin, Charles J. Norsigian, Jonathan M. Monk, Bernhard O. Palsson, Mary N. Parenteau
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Advances in nanopore-based sequencing techniques have enabled rapid characterization of genomes and transcriptomes. An emerging application of this sequencing technology is point-of-care characterization of pathogenic bacteria. However, genome assess
Externí odkaz:
https://doaj.org/article/af045dac6675475e8139376df37ddf1b