Connexins in Cancer, the Possible Role of Connexin46 as a Cancer Stem Cell-Determining Protein

Autor: Isidora M. León-Fuentes, María G. Salgado-Gil, María S. Novoa, Mauricio A. Retamal

Publikováno v: Biomolecules, Vol 13, Iss 10, p 1460 (2023)

Cancer is a widespread and incurable disease caused by genetic mutations, leading to uncontrolled cell proliferation and metastasis. Connexins (Cx) are transmembrane proteins that facilitate intercellular communication via hemichannels and gap juncti

Externí odkaz: https://doaj.org/article/0858ad0e201d43d5a498409c76cfa883

Connexin46 Expression Enhances Cancer Stem Cell and Epithelial-to-Mesenchymal Transition Characteristics of Human Breast Cancer MCF-7 Cells

Autor: Mauricio A. Retamal, Diego Herrera-Sepulveda, Manuel Varas-Godoy, Rodrigo A. Acuña

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12604, p 12604 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 22; Pages: 12604

Connexins (Cxs) are a family of proteins that form two different types of ion channels: hemichannels and gap junction channels. These channels participate in cellular communication, enabling them to share information and act as a synchronized syncyti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259b0c499e493248c6fdd84b17eef57a
http://europepmc.org/articles/PMC8624448

Connexin hemichannels in the lens

Autor: Eric C Beyer, Viviana M. Berthoud

Publikováno v: Frontiers in Physiology, Vol 5 (2014)

The normal function and survival of cells in the avascular lens is facilitated by intercellular communication through an extensive network of gap junctions formed predominantly by three connexins (Cx43, Cx46, and Cx50). In expression systems, these c

Externí odkaz: https://doaj.org/article/b0ac21210f6f42c2826c7d7304aede2b

Connexin mutants and cataracts

Autor: Eric C Beyer, Lisa eEbihara, Viviana M. Berthoud

Publikováno v: Frontiers in Pharmacology, Vol 4 (2013)

The lens is a multicellular, but avascular tissue that must stay transparent to allow normal transmission of light and focusing of it on the retina. Damage to lens cells and/or proteins can cause cataracts, opacities that disrupt these processes. The

Externí odkaz: https://doaj.org/article/3ea3448fd84645ce9461695240999dfe

The amino terminal domains of sheep Cx46 or Cx50 determine their gap junction channel open stability and unitary channel conductance

Autor: Yue, Benny

Publikováno v: Electronic Thesis and Dissertation Repository

Connexins form intercellular communication channels known as gap junctions (GJs), which are found throughout the vertebrate species. GJs formed by different connexins harbor unique channel properties that have not been fully defined. High-resolution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1548::edca128c46dcfd8b721b44638d0f0843
https://ir.lib.uwo.ca/etd/7047