Zobrazeno 1 - 10
of 1 197
pro vyhledávání: '"conformational ensembles"'
Autor:
Chih Hung Lo
Publikováno v:
Biophysica, Vol 2, Iss 4, Pp 440-451 (2022)
Tauopathies, including Alzheimer’s disease (AD), are a group of neurodegenerative disorders characterized by pathological aggregation of microtubule binding protein tau. The presence of tau neurofibrillary tangles, which are insoluble β-sheet fibr
Externí odkaz:
https://doaj.org/article/ee45fd49c8d24fbd93c4ba3259a26a5d
Autor:
Sabab Hasan Khan, Sean M Braet, Stephen John Koehler, Elizabeth Elacqua, Ganesh Srinivasan Anand, C Denise Okafor
Publikováno v:
eLife, Vol 11 (2022)
Nuclear receptors function as ligand-regulated transcription factors whose ability to regulate diverse physiological processes is closely linked with conformational changes induced upon ligand binding. Understanding how conformational populations of
Externí odkaz:
https://doaj.org/article/236457d256c9411bb678f601ffd29649
Autor:
Stephanie A Wankowicz, Saulo H de Oliveira, Daniel W Hogan, Henry van den Bedem, James S Fraser
Publikováno v:
eLife, Vol 11 (2022)
While protein conformational heterogeneity plays an important role in many aspects of biological function, including ligand binding, its impact has been difficult to quantify. Macromolecular X-ray diffraction is commonly interpreted with a static str
Externí odkaz:
https://doaj.org/article/42e8ec0d84fa4d86ba8fa90a81eae627
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Many proteins can fold into well-defined conformations. However, intrinsically-disordered proteins (IDPs) do not possess a defined structure. Moreover, folded multi-domain proteins often digress into alternative conformations. Collectively, the confo
Externí odkaz:
https://doaj.org/article/6e60b07e33744aae96ee6cff26c2e30d
Autor:
Chih Hung Lo
Publikováno v:
Bioengineering & Translational Medicine, Vol 6, Iss 3, Pp n/a-n/a (2021)
Abstract Tau is a microtubule binding protein which plays an important role in physiological functions but it is also involved in the pathogenesis of Alzheimer's disease and related tauopathies. While insoluble and β‐sheet containing tau neurofibr
Externí odkaz:
https://doaj.org/article/4427c52e1e3347d181c39bcc3f1622c9
Autor:
Sengupta, Ushnish, Strodel, Birgit
Publikováno v:
Philosophical Transactions: Biological Sciences, 2018 Jun . 373(1749), 1-7.
Externí odkaz:
https://www.jstor.org/stable/26486278
Publikováno v:
eLife, Vol 10 (2021)
Integration of binding information by macromolecular entities is fundamental to cellular functionality. Recent work has shown that such integration cannot be explained by pairwise cooperativities, in which binding is modulated by binding at another s
Externí odkaz:
https://doaj.org/article/690118aabc81462994bda1c71bc68cd8
Autor:
Cristina Paissoni, Carlo Camilloni
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The reliability and usefulness of molecular dynamics simulations of equilibrium processes rests on their statistical precision and their capability to generate conformational ensembles in agreement with available experimental knowledge. Metadynamics
Externí odkaz:
https://doaj.org/article/dd951144485c4960bf113962f6aadeda
Autor:
Greta Bianchi, Marco Mangiagalli, Alberto Barbiroli, Sonia Longhi, Rita Grandori, Carlo Santambrogio, Stefania Brocca
Publikováno v:
Biomolecules, Vol 12, Iss 4, p 561 (2022)
Intrinsically disordered proteins (IDPs) are ensembles of interconverting conformers whose conformational properties are governed by several physico-chemical factors, including their amino acid composition and the arrangement of oppositely charged re
Externí odkaz:
https://doaj.org/article/74a6d0439ad1402bb57c97fb37f25c7e