Mice Lacking JunB Are Osteopenic due to Cell-Autonomous Osteoblast and Osteoclast Defects

Autor: Kenner, Lukas, Hoebertz, Astrid, Beil, Timo, Keon, Niamh, Karreth, Florian, Eferl, Robert, Scheuch, Harald, Szremska, Agnieszka, Amling, Michael, Schorpp-Kistner, Marina, Angel, Peter, Wagner, Erwin F.

Publikováno v: The Journal of Cell Biology, 2004 Feb . 164(4), 613-623.

Externí odkaz: https://www.jstor.org/stable/1622065

Identifying Plectin Isoform Functions through Animal Models

Autor: Maria J. Castañón, Gerhard Wiche

Publikováno v: Cells, Vol 10, Iss 9, p 2453 (2021)

Plectin, a high-molecular-weight cytoskeletal linker protein, binds with high affinity to intermediate filaments of all types and connects them to junctional complexes, organelles, and inner membrane systems. In addition, it interacts with actomyosin

Externí odkaz: https://doaj.org/article/39175185af7c4ad59215f5d642f2e9c9

Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways

Autor: Ammara Abdullah, Kathleen M. Eyster, Travis Bjordahl, Peng Xiao, Erliang Zeng, Xuejun Wang

Publikováno v: Frontiers in Physiology, Vol 8 (2017)

Background: The COP9 signalosome (CSN) consisting of 8 unique protein subunits (COPS1 through COPS8) serves as the cullin deneddylase, regulating the catalytic dynamics of cullin RING ligases (CRLs), the largest family of ubiquitin ligases Background

Externí odkaz: https://doaj.org/article/3ca62fad67634ee883ca8a0cff926baa

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines

Autor: Ariane Pereira, Jeff A. Stogsdill, Gesine Saher, Peter Scheiffele, Lisa Traunmüller, Klaus-Armin Nave, Jiexin Wang, Chris J. McBain, Naosuke Hoshina, Huda Y. Zoghbi, Yu Itoh-Maruoka, Cagla Eroglu, Wei-Hsiang Huang, Fritz Benseler, Thomas Philips, Constance L. Cepko, Mateusz C. Ambrozkiewicz, Jeremy N. Kay, Hiroshi Kawabe, Vania F. Prado, Kevin T. Beier, Wenjia You, Nils Brose, Harold A. Burgess, Wei Lu, Junko Motohashi, Pascal S. Kaeser, Liqun Luo, Marco A. M. Prado, Elisabetta Furlanis, Emily Ling-Lin Pai, Kenji Sakimura, Kenji Mandai, John L.R. Rubenstein, Andrea M. Gomez, Emilie Dumontier, Michisuke Yuzaki, Hisashi Umemori, Yoshimi Takai, Jean-François Cloutier, Susanne Falkner, Laura A. Lavery, Sandra Goebbels, Matthijs Verhage, Ann Marie Craig, Cui Chen, Kenneth A. Pelkey, Wei Li, Nashat Abumaria, Joshua R. Sanes, Lin Luo, Jeffrey D. Rothstein, Joke Wortel, Jennifer L. Sinclair, Mary Anne Hutchison, Tomohiko Maruo

Publikováno v: Neuron, vol 106, iss 1
Luo, L, Ambrozkiewicz, M C, Benseler, F, Chen, C, Dumontier, E, Falkner, S, Furlanis, E, Gomez, A M, Hoshina, N, Huang, W H, Hutchison, M A, Itoh-Maruoka, Y, Lavery, L A, Li, W, Maruo, T, Motohashi, J, Pai, E L L, Pelkey, K A, Pereira, A, Philips, T, Sinclair, J L, Stogsdill, J A, Traunmüller, L, Wang, J, Wortel, J, You, W, Abumaria, N, Beier, K T, Brose, N, Burgess, H A, Cepko, C L, Cloutier, J F, Eroglu, C, Goebbels, S, Kaeser, P S, Kay, J N, Lu, W, Luo, L, Mandai, K, McBain, C J, Nave, K A, Prado, M A M, Prado, V F, Rothstein, J, Rubenstein, J L R, Saher, G, Sakimura, K, Sanes, J R, Scheiffele, P, Takai, Y, Umemori, H, Verhage, M, Yuzaki, M, Zoghbi, H Y, Kawabe, H & Craig, A M 2020, ' Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines : Prevalence of Germline Recombination and Influencing Factors ', Neuron, vol. 106, no. 1, pp. 37-65.e5 . https://doi.org/10.1016/j.neuron.2020.01.008
Neuron, 106(1), 37-65.e5. Cell Press
Neuron

The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities of unexpected germline recombination in distinct Cre driver li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a0d62fde17242aab3eee01b2747766
https://doi.org/10.1016/j.neuron.2020.01.008

Conditional genetic ablation mouse models as a tool to study cancer immunosurveillance in vivo

Autor: Dupont, Magali, Vosshenrich, Christian A. J.

Publikováno v: Methods in Molecular Biology
Methods in Molecular Biology, Humana Press/Springer Imprint, 2018, Cancer Immunosurveillance, 1884, pp.161-176. ⟨10.1007/978-1-4939-8885-3_11⟩
Methods in Molecular Biology, 2018, Cancer Immunosurveillance, 1884, pp.161-176. ⟨10.1007/978-1-4939-8885-3_11⟩

International audience; Over the last decades, it has been established that the immune system is crucial for the impediment of cancer development by recognizing and destroying transformed cells. This process has been termed cancer immunosurveillance.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::558c2823ea686e0b2c18eb6af6859824
https://hal-pasteur.archives-ouvertes.fr/pasteur-01991261