Zobrazeno 1 - 10
of 337
pro vyhledávání: '"computational immunology"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAntibodies represent a specific class of proteins produced by the adaptive immune system in response to pathogens. Mining the information embedded in antibody amino acid sequences can benefit both antibody property prediction and novel th
Externí odkaz:
https://doaj.org/article/7a3fce70fdaa45d9aaf9a7aa49af15ca
Publikováno v:
Biochemistry and Biophysics Reports, Vol 39, Iss , Pp 101745- (2024)
The oldest human coronavirus that started pandemics is severe acute respiratory syndrome virus (SARS-CoV). While SARS-CoV was eradicated, its new version, SARS-CoV2, caused the global pandemic of COVID-19. Evidence highlights the harmful events orche
Externí odkaz:
https://doaj.org/article/b1d36de4b7cb4ff4a88097718bf5b639
Autor:
Brian J. Roberts, Aimee E. Mattei, Kristina E. Howard, James L. Weaver, Hao Liu, Sandra Lelias, William D. Martin, Daniela Verthelyi, Eric Pang, Katie J. Edwards, Anne S. De Groot
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Advances in synthetic peptide synthesis have enabled rapid and cost-effective peptide drug manufacturing. For this reason, peptide drugs that were first produced using recombinant DNA (rDNA) technology are now being produced using solid- and liquid-p
Externí odkaz:
https://doaj.org/article/674dd4b85a844bff9f2eb55deb7c7e13
Autor:
Chloe H. Lee, Jaesung Huh, Paul R. Buckley, Myeongjun Jang, Mariana Pereira Pinho, Ricardo A. Fernandes, Agne Antanaviciute, Alison Simmons, Hashem Koohy
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-24 (2023)
Abstract Background T-cells play a crucial role in the adaptive immune system by triggering responses against cancer cells and pathogens, while maintaining tolerance against self-antigens, which has sparked interest in the development of various T-ce
Externí odkaz:
https://doaj.org/article/e4fa26aaefb94dcb8391be6331e31555
Autor:
Saigha Marriam, Muhammad Sher Afghan, Mazhar Nadeem, Muhammad Sajid, Muhammad Ahsan, Abdul Basit, Muhammad Wajid, Sabeen Sabri, Imran Zafar, Summya Rashid, Sheikh Arslan Sehgal, Dalal Hussien M. Alkhalifah, Wael N. Hozzein, Kow-Tong Chen, Rohit Sharma
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
There has been progressive improvement in immunoinformatics approaches for epitope-based peptide design. Computational-based immune-informatics approaches were applied to identify the epitopes of SARS-CoV-2 to develop vaccines. The accessibility of t
Externí odkaz:
https://doaj.org/article/3707cf273f6c4eb0a71a075424683c0e
Akademický článek
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Autor:
Soumya Banerjee
Publikováno v:
Interdisciplinary Description of Complex Systems, Vol 19, Iss 4, Pp 502-510 (2021)
The immune system is a distributed decentralized system that functions without any centralized control. The immune system has millions of cells that function somewhat independently and can detect and respond to pathogens with considerable speed and e
Externí odkaz:
https://doaj.org/article/57ef2eb2a7204b40a96e8f1b83081ff1
Autor:
Hesham ElAbd, Frauke Degenhardt, Tomas Koudelka, Ann-Kristin Kamps, Andreas Tholey, Petra Bacher, Tobias L. Lenz, Andre Franke, Mareike Wendorff
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-18 (2021)
Abstract Background The human leukocyte antigen (HLA) proteins play a fundamental role in the adaptive immune system as they present peptides to T cells. Mass-spectrometry-based immunopeptidomics is a promising and powerful tool for characterizing th
Externí odkaz:
https://doaj.org/article/d574fffae21e41428bede1cb6f4dcb3f
Autor:
Wesley de Jesus Lourenço, Ruy Freitas Reis, Ricardo Ruiz-Baier, Bernardo Martins Rocha, Rodrigo Weber dos Santos, Marcelo Lobosco
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Myocarditis is a general set of mechanisms that manifest themselves into the inflammation of the heart muscle. In 2017, more than 3 million people were affected by this disease worldwide, causing about 47,000 deaths. Many aspects of the origin of thi
Externí odkaz:
https://doaj.org/article/1f8e8ee3028449219212950609ceb968
Autor:
Dario F. Marzella, Farzaneh M. Parizi, Derek van Tilborg, Nicolas Renaud, Daan Sybrandi, Rafaella Buzatu, Daniel T. Rademaker, Peter A. C. ‘t Hoen, Li C. Xue
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Deeper understanding of T-cell-mediated adaptive immune responses is important for the design of cancer immunotherapies and antiviral vaccines against pandemic outbreaks. T-cells are activated when they recognize foreign peptides that are presented o
Externí odkaz:
https://doaj.org/article/56fded4c51f045779df98f600919cac8