Zobrazeno 1 - 10
of 537
pro vyhledávání: '"computational docking"'
Autor:
Shengying Lin, Xiaoyang Wang, Roy Wai-Lun Tang, Ran Duan, Ka Wing Leung, Tina Ting-Xia Dong, Sarah E. Webb, Andrew L. Miller, Karl Wah-Keung Tsim
Publikováno v:
Molecules, Vol 29, Iss 11, p 2636 (2024)
COVID-19 continues to spread around the world. This is mainly because new variants of the SARS-CoV-2 virus emerge due to genomic mutations, evade the immune system and result in the effectiveness of current therapeutics being reduced. We previously e
Externí odkaz:
https://doaj.org/article/8cbda782edb04c3c8cbb89626aaf8f58
Autor:
Nicholas O. Schneider, Kendra Gilreath, Daniel J. Burkett, Martin St. Maurice, William A. Donaldson
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 570 (2024)
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase which plays a center role in the phosphorylation of a wide variety of proteins, generally leading to their inactivation. As such, GSK-3 is viewed as a therapeutic target. An ever-increas
Externí odkaz:
https://doaj.org/article/cead14d4c2924495a6cb574a90aa61a1
Akademický článek
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Publikováno v:
Current Issues in Molecular Biology, Vol 43, Iss 3, Pp 2036-2047 (2021)
The study of the interaction between the SARS-CoV-2 spike protein and the angiotensin-converting enzyme 2 (ACE2) receptor is key to understanding binding affinity and stability. In the present report, we sought to investigate the differences between
Externí odkaz:
https://doaj.org/article/54cfde08db054e54be37de94edb964a0
Publikováno v:
Journal of Infection and Public Health, Vol 14, Iss 2, Pp 214-220 (2021)
COVID-19 has nowadays affected almost all our societies and global health systems. The latest deadly pandemic has heavily influenced both life and livelihood worldwide. SARS-CoV-2 is the causative organism of COVID-19, that is spreading and infecting
Externí odkaz:
https://doaj.org/article/7011a50839c44197aa225349731157c7
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 459-466 (2021)
The world is going through the scourge of the COVID-19 pandemic since January 2020. However, the pandemic appears to be less severe in highly dengue endemic countries. In this connection, several studies reported that sero-diagnostic tests for dengue
Externí odkaz:
https://doaj.org/article/748e0d86d94d41dab8028d83cdb81093
Autor:
Alessandro Chiadò, Francesca Bosco, Marco Bardelli, Luca Simonelli, Mattia Pedotti, Luca Marmo, Luca Varani
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2213-2222 (2021)
Laccases are among the most sought-after biocatalyst for many green applications, from biosensors to pollution remedial, because they simply need oxygen from the air to oxidize and degrade a broad range of substrates. However, natural laccases cannot
Externí odkaz:
https://doaj.org/article/e8c583e6e0014a6ca3b9a0e87ae479ce
Autor:
Prof. Kenneth K. Laali, Angela T. Zwarycz, Nicholas Beck, Dr. Gabriela L. Borosky, Dr. Manabu Nukaya, Prof. Gregory D. Kennedy
Publikováno v:
ChemistryOpen, Vol 9, Iss 8, Pp 822-834 (2020)
Abstract In an effort to combine the anti‐proliferative effect of CUR‐BF2 and CUR compounds with anti‐inflammatory benefits of non‐steroidal anti‐inflammatory drugs (NSAIDs), a library of the bis‐ and mono‐NSAID/CUR‐BF2 and NSAID/CUR
Externí odkaz:
https://doaj.org/article/8bee1724acfe4fe7b2c84d22e5cacb08
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Protein-lipid interactions are key regulators of ion channel function. Numerous ion channels, including hyperpolarization-activated cyclic-nucleotide gated (HCN) channels have been shown to be regulated by phosphoinositides (PIPs), with important imp
Externí odkaz:
https://doaj.org/article/b3cb685e749343cdbbbf212b1398f48d
Autor:
Philip Eisenberg, Leon Albert, Jonathan Teuffel, Eric Zitzow, Claudia Michaelis, Jane Jarick, Clemens Sehlke, Lisa Große, Nicole Bader, Ariane Nunes-Alves, Bernd Kreikemeyer, Hermann Schindelin, Rebecca C. Wade, Tomas Fiedler
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The strict human pathogen Streptococcus pyogenes causes infections of varying severity, ranging from self-limiting suppurative infections to life-threatening diseases like necrotizing fasciitis or streptococcal toxic shock syndrome. Here, we show tha
Externí odkaz:
https://doaj.org/article/06e0bdea46604a478a5c61687a0d7bac