Zobrazeno 1 - 10
of 439
pro vyhledávání: '"compound screening"'
Autor:
Jiajia Tang, Quan Zheng, Qi Wang, Yaru Zhao, Preeta Ananthanarayanan, Chiara Reina, Berina Šabanović, Ke Jiang, Ming-Hsin Yang, Clara Csilla Meny, Huimin Wang, Mette Ø. Agerbaek, Thomas Mandel Clausen, Tobias Gustavsson, Chenlei Wen, Felice Borghi, Alfredo Mellano, Elisabetta Fenocchio, Vanesa Gregorc, Anna Sapino, Thor G. Theander, Da Fu, Alexandra Aicher, Ali Salanti, Baiyong Shen, Christopher Heeschen
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101692- (2024)
Summary: Pancreatic ductal adenocarcinoma (PDAC) poses significant clinical challenges, often presenting as unresectable with limited biopsy options. Here, we show that circulating tumor cells (CTCs) offer a promising alternative, serving as a “liq
Externí odkaz:
https://doaj.org/article/ed0af2f0abc443e89c00860a71176afe
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Over 90% of marketed drugs are small molecules, low molecular weight organic compounds that have been discovered, designed, and developed to prompt a specific biological process in the body. Examples include antibiotics (penicillin), analgesics (para
Externí odkaz:
https://doaj.org/article/f31fa8230d5c439ca618a62ea3397293
Publikováno v:
Methods and Protocols, Vol 6, Iss 6, p 119 (2023)
Perturbation of angiogenesis is associated with a variety of diseases and pro- as well as antiangiogenic therapies are being actively explored. Additionally, unintended adverse drug effects on angiogenesis might lead to promotion of tumor progression
Externí odkaz:
https://doaj.org/article/446e8ce0abc34a028bd02639e6accb3e
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Sadanori Watanabe, Akitada Yogo, Tsuguteru Otsubo, Hiroki Umehara, Jun Oishi, Toru Kodo, Toshihiko Masui, Shigeo Takaishi, Hiroshi Seno, Shinji Uemoto, Etsuro Hatano
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Pancreatic cancer is one of the most lethal tumors. The aim of this study is to provide an effective therapeutic discovery platform for pancreatic cancer by establishing and characterizing patient-derived organoids (PDOs). Methods
Externí odkaz:
https://doaj.org/article/efe91fea083e48c7aae1df225a63007e
Autor:
Maria Florencia Ercoli, Priscila Zonzini Ramos, Rashmi Jain, Joseph Pilotte, Oliver Xiaoou Dong, Ty Thompson, Carrow I. Wells, Jonathan M. Elkins, Aled M. Edwards, Rafael M. Couñago, David H. Drewry, Pamela C. Ronald
Publikováno v:
Plant Direct, Vol 6, Iss 11, Pp n/a-n/a (2022)
Abstract One hundred twenty‐nine protein kinases, selected to represent the diversity of the rice (Oryza sativa) kinome, were cloned and tested for expression in Escherichia coli. Forty of these rice kinases were purified and screened using differe
Externí odkaz:
https://doaj.org/article/1afc7e1921544c3ea7cc365468317d17
Autor:
Dr. Patricia Korn, Arno Classen, Dr. Sudarshan Murthy, Dr. Riccardo Guareschi, Mirko M. Maksimainen, Barbara E. Lippok, Albert Galera‐Prat, Sven T. Sowa, Catharina Voigt, Prof. Dr. Giulia Rossetti, Prof. Dr. Lari Lehtiö, Prof. Dr. Carsten Bolm, Prof. Dr. Bernhard Lüscher
Publikováno v:
ChemistryOpen, Vol 10, Iss 10, Pp 939-948 (2021)
Abstract Intracellular ADP‐ribosyltransferases catalyze mono‐ and poly‐ADP‐ribosylation and affect a broad range of biological processes. The mono‐ADP‐ribosyltransferase PARP10 is involved in signaling and DNA repair. Previous studies ide
Externí odkaz:
https://doaj.org/article/0e125f0171b24e93b9aec1f09fcdc7ff
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. It has six open reading frames (orf1ab, orf3a, orf6, orf7a, orf8, and orf10), a spike protein, a membrane protein, an envelope small membrane protein, and a nucleocapsid protein, out o
Externí odkaz:
https://doaj.org/article/04b544588ea14de78c0943979ee3c011
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.