Zobrazeno 1 - 10
of 456
pro vyhledávání: '"compound screening"'
Autor:
Yosuke Funato, Mai Mimura, Kazuto Nunomura, Bangzhong Lin, Shintarou Fujii, Junichi Haruta, Hiroaki Miki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Phosphatase of regenerating liver (PRL) is an oncogenic protein that promotes tumor progression by directly binding to cyclin M (CNNM) membrane proteins and inhibiting their Mg2+ efflux activity. In this study, we have developed a high-throu
Externí odkaz:
https://doaj.org/article/3586ef48f07b4cb194e89b64ca504b67
Autor:
Blaž Andlovic, Alexander Wolf, Malgorzata Hiltmann, Bert M. Klebl, Jan Eickhoff, Christian Ottmann
Publikováno v:
SLAS Discovery, Vol 29, Iss 8, Pp 100191- (2024)
The Hippo pathway plays an important role in organ size control and tissue homeostasis. Dysregulation is involved in many pathologies, including cancer, which has attracted interest in targeting the Hippo pathway. Since the upstream components are bo
Externí odkaz:
https://doaj.org/article/25b43e58e9044192aebb9c5e2cea5ea3
Autor:
Jiajia Tang, Quan Zheng, Qi Wang, Yaru Zhao, Preeta Ananthanarayanan, Chiara Reina, Berina Šabanović, Ke Jiang, Ming-Hsin Yang, Clara Csilla Meny, Huimin Wang, Mette Ø. Agerbaek, Thomas Mandel Clausen, Tobias Gustavsson, Chenlei Wen, Felice Borghi, Alfredo Mellano, Elisabetta Fenocchio, Vanesa Gregorc, Anna Sapino, Thor G. Theander, Da Fu, Alexandra Aicher, Ali Salanti, Baiyong Shen, Christopher Heeschen
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101692- (2024)
Summary: Pancreatic ductal adenocarcinoma (PDAC) poses significant clinical challenges, often presenting as unresectable with limited biopsy options. Here, we show that circulating tumor cells (CTCs) offer a promising alternative, serving as a “liq
Externí odkaz:
https://doaj.org/article/ed0af2f0abc443e89c00860a71176afe
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Over 90% of marketed drugs are small molecules, low molecular weight organic compounds that have been discovered, designed, and developed to prompt a specific biological process in the body. Examples include antibiotics (penicillin), analgesics (para
Externí odkaz:
https://doaj.org/article/f31fa8230d5c439ca618a62ea3397293
Akademický článek
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Akademický článek
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Autor:
Sadanori Watanabe, Akitada Yogo, Tsuguteru Otsubo, Hiroki Umehara, Jun Oishi, Toru Kodo, Toshihiko Masui, Shigeo Takaishi, Hiroshi Seno, Shinji Uemoto, Etsuro Hatano
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Pancreatic cancer is one of the most lethal tumors. The aim of this study is to provide an effective therapeutic discovery platform for pancreatic cancer by establishing and characterizing patient-derived organoids (PDOs). Methods
Externí odkaz:
https://doaj.org/article/efe91fea083e48c7aae1df225a63007e
Publikováno v:
Methods and Protocols, Vol 6, Iss 6, p 119 (2023)
Perturbation of angiogenesis is associated with a variety of diseases and pro- as well as antiangiogenic therapies are being actively explored. Additionally, unintended adverse drug effects on angiogenesis might lead to promotion of tumor progression
Externí odkaz:
https://doaj.org/article/446e8ce0abc34a028bd02639e6accb3e
Autor:
Maria Florencia Ercoli, Priscila Zonzini Ramos, Rashmi Jain, Joseph Pilotte, Oliver Xiaoou Dong, Ty Thompson, Carrow I. Wells, Jonathan M. Elkins, Aled M. Edwards, Rafael M. Couñago, David H. Drewry, Pamela C. Ronald
Publikováno v:
Plant Direct, Vol 6, Iss 11, Pp n/a-n/a (2022)
Abstract One hundred twenty‐nine protein kinases, selected to represent the diversity of the rice (Oryza sativa) kinome, were cloned and tested for expression in Escherichia coli. Forty of these rice kinases were purified and screened using differe
Externí odkaz:
https://doaj.org/article/1afc7e1921544c3ea7cc365468317d17
Akademický článek
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