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pro vyhledávání: '"complications/genetics/metabolism"'
Autor:
Bénédicte Oulès, Patrizia Paterlini-Bréchot, Dolores Del Prete, Mounia Chami, Inger Lauritzen, Barbara Greco, Xuexin Zhang, Frédéric Checler, Sébastien Moreno, Mohamed Trebak, Jean Sevalle, Fabio Benfenati
Publikováno v:
The Journal of Neuroscience. 32:11820-11834
In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium (Ca2+) homeostasis has been linked to presenilins, the catalytic core in γ-secretase complexes cleaving the amyloid precursor protein (APP), thereby generating amy