Zobrazeno 1 - 10
of 7 721
pro vyhledávání: '"complex traits"'
Autor:
Katelynne M. Collins, Elisabeth Howansky, Sarah C. Macon-Foley, Maria E. Adonay, Vijay Shankar, Richard F. Lyman, Nestor Octavio Nazario-Yepiz, Jordyn K. Brooks, Rachel A. Lyman, Trudy F. C. Mackay, Robert R. H. Anholt
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-14 (2024)
Abstract Background 4-methylimidazole is a ubiquitous and potentially carcinogenic environmental toxicant. Genetic factors that contribute to variation in susceptibility to its toxic effects are challenging to assess in human populations. We used the
Externí odkaz:
https://doaj.org/article/e59933fe43b04c80965ccab72c2b6d57
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Heritability partitioning approaches estimate the contribution of different functional classes, such as coding or regulatory variants, to the genetic variance. This information allows a better understanding of the genetic architec
Externí odkaz:
https://doaj.org/article/95dc3d1f3dda461eb1c06ae7d9eabc93
Autor:
Winter S. Bruner, Struan F. A. Grant
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Since the turn of the 21st century, genome-wide association study (GWAS) have successfully identified genetic signals associated with a myriad of common complex traits and diseases. As we transition from establishing robust genetic associations with
Externí odkaz:
https://doaj.org/article/0a142b1d156342299832526fc4c2c2c1
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-24 (2024)
Abstract Background Telomeres form repeated DNA sequences at the ends of chromosomes, which shorten with each cell division. Yet, factors modulating telomere attrition and the health consequences thereof are not fully understood. To address this, we
Externí odkaz:
https://doaj.org/article/c65c7c7666ae4dff87fa410c20257de2
Autor:
Yuka Suzuki, Hervé Ménager, Bryan Brancotte, Raphaël Vernet, Cyril Nerin, Christophe Boetto, Antoine Auvergne, Christophe Linhard, Rachel Torchet, Pierre Lechat, Lucie Troubat, Michael H. Cho, Emmanuelle Bouzigon, Hugues Aschard, Hanna Julienne
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100319- (2024)
Summary: Since the first genome-wide association studies (GWASs), thousands of variant-trait associations have been discovered. However, comprehensively mapping the genetic determinant of complex traits through univariate testing can require prohibit
Externí odkaz:
https://doaj.org/article/a4dbb25453d64cee9640add760970ad8
Akademický článek
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Akademický článek
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Autor:
Matthias Weith, Jan Großbach, Mathieu Clement‐Ziza, Ludovic Gillet, María Rodríguez‐López, Samuel Marguerat, Christopher T Workman, Paola Picotti, Jürg Bähler, Ruedi Aebersold, Andreas Beyer
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 8, Pp 1-21 (2023)
Abstract The complexity of many cellular and organismal traits results from the integration of genetic and environmental factors via molecular networks. Network structure and effect propagation are best understood at the level of functional modules,
Externí odkaz:
https://doaj.org/article/4f972d70022840c5813a7645a1b8d926
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/e827a232128e4509aeba9a0b707deec2
Autor:
Hooman Allayee, Charles R Farber, Marcus M Seldin, Evan Graehl Williams, David E James, Aldons J Lusis
Publikováno v:
eLife, Vol 12 (2023)
Quantitative traits are often complex because of the contribution of many loci, with further complexity added by environmental factors. In medical research, systems genetics is a powerful approach for the study of complex traits, as it integrates int
Externí odkaz:
https://doaj.org/article/02a567f1967b4dd08c0627ee97eba3b3