TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models

Autor: Giacomo P. Comi, Amalia Gastaldelli, Roberto Piciotti, Anna Ludovica Fracanzani, S. Sabatini, Marica Meroni, Paola Dongiovanni, Massimiliano Ruscica, Giorgio Soardo, Anna Alisi, Luca Miele, Fabrizia Carli, Francesco Fortunato, Chiara Macchi, Veronica Erconi, Miriam Longo, Dario Ronchi, Erika Paolini, Luca Valenti

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 759-788 (2022)

Background & Aims The I148M Patatin-like Phospholipase Domain-containing 3 (PNPLA3), the rs641738 in the Membrane bound O-acyltransferase domain containing 7-transmembrane channel-like 4 (MBOAT7-TMC4) locus, and the E167K Transmembrane 6 Superfamily

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07a31c4805b1bb37b98045b846a635c
http://hdl.handle.net/11390/1218302

Methylsulfonylmethane inhibits cortisol‑induced stress through p53‑mediated SDHA/HPRT1 expression in racehorse skeletal muscle cells: A primary step against exercise stress

Autor: Yeong‑Min Park, Il Ho Kim, Dong Young Kang, Nipin Sp, Young Mok Yang, Hak Kyo Lee, Kyoung Jin Jang, Do Hoon Kim, Hyo Gun Lee, Byung Wook Cho

Publikováno v: Experimental and Therapeutic Medicine

Cortisol is a hormone involved in stress during exercise. The application of natural compounds is a new potential approach for controlling cortisol-induced stress. Tumour suppressor protein p53 is activated during cellular stress. Succinate dehydroge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db0db5f8b38ba33c78f7b4d7e850302
https://doi.org/10.3892/etm.2019.8196

Chemical Nature and Reaction Mechanisms of the Molybdenum Cofactor of Xanthine Oxidoreductase

Autor: Teruo Kusano, Ken Okamoto, Takeshi Nishino

Publikováno v: Current Pharmaceutical Design

Xanthine oxidoreductase (XOR), a complex flavoprotein, catalyzes the metabolic reactions leading from hypoxanthine to xanthine and from xanthine to urate, and both reactions take place at the molybdenum cofactor. The enzyme is a target of drugs for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f986e7605703b394e420ab7e6626da6
https://doi.org/10.2174/1381612811319140010

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