Efficacy and safety of vibrating capsule for functional constipation (VICONS): A randomised, double-blind, placebo-controlled, multicenter trial

Autor: Jia-Hui Zhu, Yang-Yang Qian, Jun Pan, Chen He, Yu Lan, Wei-Na Chen, Bang-Mao Wang, Wei Zhao, Jing-Nan Li, Xiao-Qing Li, Bin Lv, Yi-Hong Fan, Xiu-Li Zuo, Zhen Li, Duo-Wu Zou, Zhao-Shen Li, Zhuan Liao

Publikováno v: EClinicalMedicine, Vol 47, Iss , Pp 101407- (2022)

Summary: Background: Functional constipation (FC) is an intractable disease that carries large financial burden as well as emotional and physical stress. We aimed to assess the efficacy and safety of the newly developed smartphone-controlled vibratin

Externí odkaz: https://doaj.org/article/e0969239bc7f49fe9274d6c07b8c3948

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The effect of 'Zesy002' kiwifruit (

Autor: Sarah L, Eady, Alison J, Wallace, Christine A, Butts, Duncan, Hedderley, Lynley, Drummond, Juliet, Ansell, Richard B, Gearry

Publikováno v: Journal of Nutritional Science

Functional gastrointestinal disorders including constipation affect up to 14 % of the world's population. Treatment is difficult and challenging resulting in a need for alternative safe and effective therapies. The present study investigated whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b749049f5716e35dcd6802086ceca20
https://pubmed.ncbi.nlm.nih.gov/31080591

Randomized clinical trial: efficacy and safety of plecanatide in the treatment of chronic idiopathic constipation

Autor: Bernadette Hickey, Patrick Griffin, Laura Barrow, Kunwar Shailubhai, Michael DeMicco

Publikováno v: Therapeutic Advances in Gastroenterology
Therapeutic Advances in Gastroenterology, Vol 10 (2017)

Background: Plecanatide, with the exception of a single amino acid replacement, is identical to human uroguanylin and is approved in the United States for adults with chronic idiopathic constipation (CIC). This double-blind, placebo-controlled, phase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7144e4968958958951d455b2dc5b00
https://pubmed.ncbi.nlm.nih.gov/29147135

CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation

Autor: Marc H. Levin, Alan S. Verkman, Liang Sun, Puay-Wah Phuan, Peter M. Haggie, Sujin Lee, Joseph Tan, Tonghui Ma, Jay R. Thiagarajah, Onur Cil

Publikováno v: Cellular and molecular gastroenterology and hepatology, vol 2, iss 3
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 3, Pp 317-327 (2016)

Background & Aims: Constipation is a common clinical problem that negatively impacts quality of life and is associated with significant health care costs. Activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145211fd3cfbb1c1979a5b6c97bcbcfe
https://escholarship.org/uc/item/8sj8j8wj