Zobrazeno 1 - 10
of 312
pro vyhledávání: '"complement regulation"'
Autor:
Alexandra Gerogianni, Laura M. Baas, Dick J. Sjöström, Nicole C. A. J. van de Kar, Marit Pullen, Siem J. van de Peppel, Per H. Nilsson, Lambertus P. van den Heuvel
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Factor I (FI) is an essential regulator of the complement system. Together with co-factors, FI degrades C3b, which inhibits further complement activation. Genetic mutations in FI are associated with pathological conditions like age-related macular de
Externí odkaz:
https://doaj.org/article/8c1fc88df0f24e1aa4fbde43618f12be
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1473-1486 (2023)
Human complement is the first line of defence against invading pathogens and is involved in tissue homeostasis. Complement-targeted therapies to treat several diseases caused by a dysregulated complement are highly desirable. Despite huge efforts inv
Externí odkaz:
https://doaj.org/article/1cb2749bacb5487f8b7c32eb72d5cf63
Autor:
Sofiya Pisarenka, Nicole C. Meyer, Xue Xiao, Renee Goodfellow, Carla M. Nester, Yuzhou Zhang, Richard J. H. Smith
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionC3 glomerulopathies (C3G) are ultra-rare complement-mediated diseases that lead to end-stage renal disease (ESRD) within 10 years of diagnosis in ~50% of patients. Overactivation of the alternative pathway (AP) of complement in the fluid
Externí odkaz:
https://doaj.org/article/278dc68f339840d88429924d9bfc4547
Autor:
Arshad M. Khanani, MD, MA, Raj K. Maturi, MD, Nika Bagheri, MD, Benjamin Bakall, MD, PhD, David S. Boyer, MD, Stephen S. Couvillion, MD, Dilsher S. Dhoot, MD, Nancy M. Holekamp, MD, Karim N. Jamal, MD, Dennis M. Marcus, MD, Dante Pieramici, MD, Aamir A. Aziz, BS, Kiran C. Patki, MD, William Z. Bridges, Jr., MD, Samuel B. Barone, MD
Publikováno v:
Ophthalmology Science, Vol 2, Iss 2, Pp 100154- (2022)
Purpose: To establish the safety, tolerability, pharmacokinetics, and pharmacodynamics of an intravitreal injection of recombinant human complement factor H (CFH), GEM103, in individuals with genetically defined age-related macular degeneration (AMD)
Externí odkaz:
https://doaj.org/article/007c8c367e964d47b7fc962c7e0acaa8
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background The epidermal growth factor receptor (EGFR) is pivotal for growth of epithelial cells and is overexpressed in several epithelial cancers like head and neck squamous cell carcinoma (HNSCC). EGFR signalling is also involved in diver
Externí odkaz:
https://doaj.org/article/63ecd5e80f5d40cc966e5ab04eada4d5
Autor:
Alexandra Papp, Krisztián Papp, Barbara Uzonyi, Marcell Cserhalmi, Ádám I. Csincsi, Zsóka Szabó, Zsófia Bánlaki, David Ermert, Zoltán Prohászka, Anna Erdei, Viviana P. Ferreira, Anna M. Blom, Mihály Józsi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in re
Externí odkaz:
https://doaj.org/article/8845e90466f14bc1b6c749db85996ae8
Akademický článek
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Akademický článek
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Autor:
Gautam, Avneesh Kumar, Panse, Yogesh, Ghosh, Payel, Reza, Malik Johid, Mullick, Jayati, Sahu, Arvind
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2015 Oct . 112(41), 12794-12799.
Externí odkaz:
https://www.jstor.org/stable/26465499
Autor:
Ilia A. Krenev, Ekaterina S. Umnyakova, Igor E. Eliseev, Yaroslav A. Dubrovskii, Nikolay P. Gorbunov, Vladislav A. Pozolotin, Alexei S. Komlev, Pavel V. Panteleev, Sergey V. Balandin, Tatiana V. Ovchinnikova, Olga V. Shamova, Mikhail N. Berlov
Publikováno v:
Marine Drugs, Vol 18, Iss 12, p 631 (2020)
Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also are able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins and thereby modulate compl
Externí odkaz:
https://doaj.org/article/2ea4dad3a6164fce8e7f5b6022fa0dad