An integrative analysis of single-cell and bulk transcriptome and bidirectional mendelian randomization analysis identified C1Q as a novel stimulated risk gene for Atherosclerosis

Autor: Hong-Kai Cui, Chao-Jie Tang, Yu Gao, Zi-Ang Li, Jian Zhang, Yong-Dong Li

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

BackgroundThe role of complement component 1q (C1Q) related genes on human atherosclerotic plaques (HAP) is less known. Our aim is to establish C1Q associated hub genes using single-cell RNA sequencing (scRNA-seq) and bulk RNA analysis to diagnose an

Externí odkaz: https://doaj.org/article/09757d417c044b67b81100e5e9c007bf

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Initiators of Classical and Lectin Complement Pathways Are Differently Engaged after Traumatic Brain Injury-Time-Dependent Changes in the Cortex, Striatum, Thalamus and Hippocampus in a Mouse Model

Autor: Katarzyna Pawlik, Agata Ciechanowska, Joanna Mika, Katarzyna Ciapała, Maria Grazia De Simoni, Domenico Mercurio, Marco Oggioni

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 45, p 45 (2021)
Volume 22
Issue 1

The complement system is involved in promoting secondary injury after traumatic brain injury (TBI), but the roles of the classical and lectin pathways leading to complement activation need to be clarified. To this end, we aimed to determine the abili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc41815fba1478762b29b309465287e
https://pubmed.ncbi.nlm.nih.gov/33375205

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Initiators of Classical and Lectin Complement Pathways Are Differently Engaged after Traumatic Brain Injury-Time-Dependent Changes in the Cortex, Striatum, Thalamus and Hippocampus in a Mouse Model.

Autor: Ciechanowska A; Department of Pain Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland., Ciapała K; Department of Pain Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland., Pawlik K; Department of Pain Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland., Oggioni M; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, 20156 Milan, Italy., Mercurio D; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, 20156 Milan, Italy., De Simoni MG; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, 20156 Milan, Italy., Mika J; Department of Pain Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2020 Dec 22; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 22.