Zobrazeno 1 - 10
of 68
pro vyhledávání: '"common light chain"'
Publikováno v:
Antibodies, Vol 13, Iss 1, p 14 (2024)
Bispecific antibodies have gained increasing popularity as therapeutics as they enable novel activities that cannot be achieved with monospecific antibodies. Some of the most popular bispecific formats are molecules in which two Fab arms with differe
Externí odkaz:
https://doaj.org/article/c23df2f5d0214866b8a5840765d9f0ed
Autor:
Julia Harwardt, Stefania C. Carrara, Jan P. Bogen, Katrin Schoenfeld, Julius Grzeschik, Björn Hock, Harald Kolmar
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
To construct a trispecific IgG-like antibody at least three different binding moieties need to be combined, which results in a complex architecture and challenging production of these molecules. Here we report for the first time the construction of t
Externí odkaz:
https://doaj.org/article/9fb531027f17410a9441b28858737aba
Autor:
Jie Zhao, Liangfeng Jiang, Haodong Yang, Lan Deng, Xiaoqing Meng, Jian Ding, Sixing Yang, Le Zhao, Wei Xu, Xiaolong Wang, Zhenping Zhu, Haomin Huang
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Targeting PD1/PDL1 with blocking antibodies for cancer therapy has shown promising benefits in the clinic, but only approximately 20–30% of patients develop durable clinical responses to the treatment. Bispecific antibodies (BsAbs) that combine PD1
Externí odkaz:
https://doaj.org/article/abe74d264bc64d0e9f08fbe9e8d21e43
Autor:
Daniel Klewinghaus, Lukas Pekar, Paul Arras, Simon Krah, Bernhard Valldorf, Harald Kolmar, Stefan Zielonka
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
A subset of antibodies found in cattle comprises ultralong CDR-H3 regions of up to 70 amino acids. Interestingly, this type of immunoglobulin usually pairs with the single germline VL gene, V30 that is typically very conserved in sequence. In this wo
Externí odkaz:
https://doaj.org/article/bc68c3fe8b60429f93c5ed5a6714663e
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Natural killer cell engagers gained enormous interest in recent years due to their potent anti-tumor activity and favorable safety profile. Simultaneously, chicken-derived antibodies entered clinical studies paving the way for avian-derived therapeut
Externí odkaz:
https://doaj.org/article/a90d47a64eea4424ba866d67b3ea3e30
Autor:
Danyang Gong, Timothy P. Riley, Krzysztof P. Bzymek, Ana R. Correia, Danqing Li, Christopher Spahr, John H. Robinson, Ryan B. Case, Zhulun Wang, Fernando Garces
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Bispecific antibodies, engineered to recognize two targets simultaneously, demonstrate exceptional clinical potential for the therapeutic intervention of complex diseases. However, these molecules are often composed of multiple polypeptide chains of
Externí odkaz:
https://doaj.org/article/04cf260fbbe1401588e0686a93d17f29
Autor:
Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman, Philip A. Leighton
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be th
Externí odkaz:
https://doaj.org/article/596042433b2b41438fed42a477dc55c2
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Bispecific (BsAb) and biparatopic (BpAb) antibodies emerged as promising formats for therapeutic biologics exhibiting tailor-made functional properties. Over recent years, chicken-derived antibodies have gained traction for diagnostic and therapeutic
Externí odkaz:
https://doaj.org/article/3f3672396f1b46d3abe7207446757a2f