Challenges in validation of combination treatment strategies for CRC using patient-derived organoids

Autor: Valentin Benboubker, George M. Ramzy, Sacha Jacobs, Patrycja Nowak-Sliwinska

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-19 (2024)

Abstract Patient-derived organoids (PDOs) established from tissues from various tumor types gave the foundation of ex vivo models to screen and/or validate the activity of many cancer drug candidates. Due to their phenotypic and genotypic similarity

Externí odkaz: https://doaj.org/article/010b61716bf24686873cba423601682b

IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐Cov‐2) with digital drug development

Autor: Agata Blasiak, Jhin Jieh Lim, Shirley Gek Kheng Seah, Theodore Kee, Alexandria Remus, De Hoe Chye, Pui San Wong, Lissa Hooi, Anh T. L. Truong, Nguyen Le, Conrad E. Z. Chan, Rishi Desai, Xianting Ding, Brendon J. Hanson, Edward Kai‐Hua Chow, Dean Ho

Publikováno v: Bioengineering & Translational Medicine, Vol 6, Iss 1, Pp n/a-n/a (2021)

Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) led to multiple drug repurposing clinical trials that have yielded largely uncertain outcomes. To overcome this challenge, we used IDentif.AI, a platform that

Externí odkaz: https://doaj.org/article/3bdb703644b14f66b5677f820eca6cec

Management of Drug Resistance in Mantle Cell Lymphoma

Autor: Roué, Gaël, Sola, B., Universitat Autònoma de Barcelona

Publikováno v: Cancers
Cancers, MDPI, 2020, 12, ⟨10.3390/cancers12061565⟩
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Cancers, Vol 12, Iss 1565, p 1565 (2020)
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol

International audience; Mantle cell lymphoma (MCL) is a rare but aggressive B-cell hemopathy characterized by the translocation t(11;14)(q13;q32) that leads to the overexpression of the cell cycle regulatory protein cyclin D1. This translocation is t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7158d95dc792ba6d98c8ad7fc407408c
https://hal-normandie-univ.archives-ouvertes.fr/hal-02866782/document

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer

Autor: Uchini S. Kosgodage, Rhys Mould, Aine B. Henley, Alistair V. Nunn, Geoffrey W. Guy, E. L. Thomas, Jameel M. Inal, Jimmy D. Bell, Sigrun Lange

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)
Frontiers in Pharmacology

Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells and involved in intercellular communication through transfer of proteins and genetic material. EMV release is also associated with various pathologies, includin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc43ba20c8e36c4ee6bfa094722f2209