Zobrazeno 1 - 10
of 1 641
pro vyhledávání: '"co-chaperone"'
Autor:
Brianna Ball, Arjun Sukumaran, Samanta Pladwig, Samiha Kazi, Norris Chan, Effie Honeywell, Manuela Modrakova, Jennifer Geddes-McAlister
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT The increasing prevalence of invasive fungal pathogens is dramatically changing the clinical landscape of infectious diseases, posing an imminent threat to public health. Specifically, Cryptococcus neoformans, the human opportunistic pathoge
Externí odkaz:
https://doaj.org/article/260f1dcdac5e4ec29152686e72d8390d
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Introduction: The protein folding process is very sensitive to environmental conditions. Many possibilities in the form of numerous pathways for this process can—if an incorrect one is chosen—lead to the creation of forms described as misfolded.
Externí odkaz:
https://doaj.org/article/a628075058ca411d8507cfb7396b1176
Autor:
Huiyun Wei, Yingying Zhang, Yilin Jia, Xunan Chen, Tengda Niu, Aniruddha Chatterjee, Pengxing He, Guiqin Hou
Publikováno v:
MedComm, Vol 5, Iss 2, Pp n/a-n/a (2024)
Abstract Heat shock protein 90 (Hsp90) is a predominant member among Heat shock proteins (HSPs), playing a central role in cellular protection and maintenance by aiding in the folding, stabilization, and modification of diverse protein substrates. It
Externí odkaz:
https://doaj.org/article/e5f81c2e18974d8194573495cda7e17b
Autor:
Alena Welters, Oliver Nortmann, Laura Wörmeyer, Clemens Freiberg, Daniel Eberhard, Nadine Bachmann, Carsten Bergmann, Ertan Mayatepek, Thomas Meissner, Sebastian Kummer
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1270 (2024)
The BiP co-chaperone DNAJC3 protects cells during ER stress. In mice, the deficiency of DNAJC3 leads to beta-cell apoptosis and the gradual onset of hyperglycemia. In humans, biallelic DNAJC3 variants cause a multisystem disease, including early-onse
Externí odkaz:
https://doaj.org/article/002ad8332aca42f882b49a9d746753ad
Akademický článek
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Autor:
Miebaka Jamabo, Stephen John Bentley, Paula Macucule-Tinga, Praise Tembo, Adrienne Lesley Edkins, Aileen Boshoff
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
African trypanosomiasis is a neglected tropical disease caused by Trypanosoma brucei (T. brucei) and spread by the tsetse fly in sub-Saharan Africa. The trypanosome relies on heat shock proteins for survival in the insect vector and mammalian host. H
Externí odkaz:
https://doaj.org/article/0efb577e8f434e8d830ea80077828b9b
Akademický článek
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Akademický článek
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Autor:
S. Mark Roe, Zsolt Török, Andrew McGown, Ibolya Horváth, John Spencer, Tamás Pázmány, László Vigh, Chrisostomos Prodromou
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1051 (2023)
Functional changes in chaperone systems play a major role in the decline of cognition and contribute to neurological pathologies, such as Alzheimer’s disease (AD). While such a decline may occur naturally with age or with stress or trauma, the mech
Externí odkaz:
https://doaj.org/article/08be2b23ecf04e69a5cf2cce0b6b8737
Autor:
Mina Ardestani, Zahra Khorsandi, Fariba Keshavarzipour, Siavash Iravani, Hojjat Sadeghi-Aliabadi, Rajender S. Varma
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2220 (2022)
Heat shock proteins (Hsps) have garnered special attention in cancer therapy as molecular chaperones with regulatory/mediatory effects on folding, maintenance/stability, maturation, and conformation of proteins as well as their effects on prevention
Externí odkaz:
https://doaj.org/article/76e5fb6054dd4d068b387d71103431b1