Zobrazeno 1 - 10
of 253
pro vyhledávání: '"clustered DNA damage"'
Autor:
Naoya Shikazono, Ken Akamatsu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Clustered DNA damage, when multiple lesions are generated in close proximity, has various biological consequences, including cell death, chromosome aberrations, and mutations. It is generally perceived as a hallmark of ionizing radiation. Th
Externí odkaz:
https://doaj.org/article/87c8f38024e84c4f98e1ec0815fe396b
Autor:
Bolesław T. Karwowski
Publikováno v:
Molecules, Vol 29, Iss 12, p 2754 (2024)
The genome—the source of life and platform of evolution—is continuously exposed to harmful factors, both extra- and intra-cellular. Their activity causes different types of DNA damage, with approximately 80 different types of lesions having been
Externí odkaz:
https://doaj.org/article/cd7e63596fb046a79ad995823685e671
Autor:
Boleslaw T. Karwowski
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5962 (2024)
The genome is continuously exposed to a variety of harmful factors that result in a significant amount of DNA damage. This article examines the influence of a multi-damage site containing oxidized imino-allantoin (OXIa) and 7,8-dihydro-8-oxo-2′-deo
Externí odkaz:
https://doaj.org/article/a3ae105c0a7640dca045bf4ab776d9ba
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Akademický článek
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Akademický článek
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Autor:
Boleslaw T. Karwowski
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8570 (2023)
Genetic information stored in a DNA base sequence is continuously exposed to harmful factors. It has been determined that 9 × 104 different DNA damage events occur in a single human cell every 24 h. Of these, 7,8-dihydro-8-oxo-guanosine (OXOG) is on
Externí odkaz:
https://doaj.org/article/f43065ea33cb4963a81c3df7a6910846
Chromatin and the Cellular Response to Particle Radiation-Induced Oxidative and Clustered DNA Damage
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Exposure to environmental ionizing radiation is prevalent, with greatest lifetime doses typically from high Linear Energy Transfer (high-LET) alpha particles via the radioactive decay of radon gas in indoor air. Particle radiation is highly genotoxic
Externí odkaz:
https://doaj.org/article/a299150213254c238232ba3ef65d20b7
Autor:
Bolesław T. Karwowski
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 881 (2023)
The genetic information stored in the nucleobase sequence is continuously exposed to harmful extra- and intra-cellular factors, which can lead to different types of DNA damage, with more than 70 lesion types identified so far. In this article, the in
Externí odkaz:
https://doaj.org/article/87e5a36877fd47be89a8e1938518cd82
Autor:
Bolesław T. Karwowski
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5361 (2023)
Genetic information, irrespective of cell type (normal or cancerous), is exposed to a range of harmful factors, which can lead to more than 80 different types of DNA damage. Of these, oxoG and FapyG have been identified as the most abundant in normox
Externí odkaz:
https://doaj.org/article/1bf257c1817240c2a5ec488314fc335a