Zobrazeno 1 - 10
of 399
pro vyhledávání: '"cleavable linker"'
Autor:
Xin-Ze Wu, Hua-Ming Xiao, Na An, Pei-Rong Bai, Yan-Zhen Wang, Azamat Temerdashev, Quan-Fei Zhu, Yu-Qi Feng
Publikováno v:
Journal of Chromatography Open, Vol 6, Iss , Pp 100154- (2024)
The chemoselective probe technique combines the benefits of chemical derivatization and solid-phase extraction, allowing for simultaneous enhancement of analyte ionization efficiency, reduction of matrix interference, and improvement in chromatograph
Externí odkaz:
https://doaj.org/article/f90ef90c441742a3b9f14d317389cf63
Autor:
Watts, Andrew M. 1, 2, Hughes, Caitlyn J. 1, 3, Clausen, Gavin A. 1, 4, Yanar, Pamira 5, Wolff, Evan J. 6, Rubio, Phoebe R. 7, Stuart, Natalie M. 8, Shugrue, Christopher R. ⁎, 9
Publikováno v:
In Bioorganic Chemistry January 2025 154
Autor:
Ritchu Babbar, Vanya, Aarti Bassi, Rashmi Arora, Ankur Aggarwal, Pranay Wal, Sunil Kumar Dwivedi, Salma Alolayan, Monica Gulati, Celia Vargas-De-La-Cruz, Tapan Behl, Shreesh Ojha
Publikováno v:
Heliyon, Vol 9, Iss 11, Pp e21425- (2023)
A nascent category of anticancer therapeutic drugs called antibody-drug conjugates (ADCs) relate selectivity of aimed therapy using chemotherapeutic medicines with high cytotoxic power. Progressive linker technology led to the advancement of more eff
Externí odkaz:
https://doaj.org/article/6aa9311d4cee4112aee5153ac41e69f8
Autor:
Jina Ryu, Sung Jae Yang, Boram Son, Haein Lee, Jongmin Lee, Jinmyoung Joo, Hee Ho Park, Tai Hyun Park
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology, Vol 50, Iss 1, Pp 278-285 (2022)
As the acute lymphoblastic leukaemia (ALL) develops, expression of L-asparaginase (ASNase) protein is known to decrease. Therefore, deficiency of the ASNase protein would be regarded as one of the significant indications of the ALL. For the treatment
Externí odkaz:
https://doaj.org/article/f464ded919634dd497b1e5ec0fbfcae4
Akademický článek
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Autor:
Marco Zambra, Ivan Ranđelović, Francesco Talarico, Adina Borbély, Laura Svajda, József Tóvári, Gábor Mező, Lizeth Bodero, Sveva Colombo, Federico Arrigoni, Elettra Fasola, Silvia Gazzola, Umberto Piarulli
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Antibody-Drug Conjugates (ADCs) and Small Molecule-Drug Conjugates (SMDCs) represent successful examples of targeted drug-delivery technologies for overcoming unwanted side effects of conventional chemotherapy in cancer treatment. In both strategies,
Externí odkaz:
https://doaj.org/article/8398d4cb126548328281d797762b4133
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 10, Iss 5, Pp 434-443 (2020)
As a powerful tool to advance drug discovery, molecular imaging may provide new insights into the process of drug effect and therapy at cellular and molecular levels. When compared with other detection methods, fluorescence-based strategies are highl
Externí odkaz:
https://doaj.org/article/97ca6387bcd44c509cb0e9c1789eddf5
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
Pei She Loh, Volker Patzel
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 370 (2023)
Covalently closed dumbbell-shaped DNA delivery vectors comprising the double-stranded gene(s) of interest and single-stranded hairpin loops on both ends represent a safe, stable and efficacious alternative to viral and other non-viral DNA-based vecto
Externí odkaz:
https://doaj.org/article/d3ee932300ab4613a64b06273217fc31
Publikováno v:
Molecules, Vol 27, Iss 15, p 4959 (2022)
Radioligand therapy (RLT) is an emergent drug class for cancer treatment. The dose administered to cancer patients is constrained by the radiation exposure to normal tissues to maintain an appropriate therapeutic index. When a radiopharmaceutical or
Externí odkaz:
https://doaj.org/article/24feef95111b425c8a70078e3b4405a8