A citric acid cycle-deficient Escherichia coli as an efficient chassis for aerobic fermentations.

Autor: Zhou H; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, China.; University of Chinese Academy of Sciences, 100049, Beijing, China., Zhang Y; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, China.; University of Chinese Academy of Sciences, 100049, Beijing, China., Long CP; Department of Chemical and Biomolecular Engineering, Metabolic Engineering and Systems Biology Laboratory, University of Delaware, Newark, DE, 19716, USA., Xia X; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China., Xue Y; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, China., Ma Y; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, China. mayanhe@im.ac.cn., Antoniewicz MR; Department of Chemical and Biomolecular Engineering, Metabolic Engineering and Systems Biology Laboratory, University of Delaware, Newark, DE, 19716, USA. mranton@umich.edu.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA. mranton@umich.edu., Tao Y; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, China. taoyong@im.ac.cn.; University of Chinese Academy of Sciences, 100049, Beijing, China. taoyong@im.ac.cn., Lin B; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, China. linbx@im.ac.cn.; University of Chinese Academy of Sciences, 100049, Beijing, China. linbx@im.ac.cn.

Publikováno v: Nature communications [Nat Commun] 2024 Mar 15; Vol. 15 (1), pp. 2372. Date of Electronic Publication: 2024 Mar 15.

Studying lysine acetylation of citric acid cycle enzymes by genetic code expansion.

Autor: Fatema N; Cell and Molecular Biology Program, University of Arkansas, Fayetteville, Arkansas, USA., Fan C; Cell and Molecular Biology Program, University of Arkansas, Fayetteville, Arkansas, USA.; Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas, USA.

Publikováno v: Molecular microbiology [Mol Microbiol] 2023 May; Vol. 119 (5), pp. 551-559. Date of Electronic Publication: 2023 Mar 13.

Characterization of pyruvate metabolism and citric acid cycle patterns predicts response to immunotherapeutic and ferroptosis in gastric cancer

Autor: Xu Wang, Bing Xu, Jing Du, Jun Xia, Guojie Lei, Chaoting Zhou, Jiayu Hu, Yinhao Zhang, Sufeng Chen, Fangchun Shao, Jiyun Yang, Yanchun Li

Publikováno v: Cancer Cell International, Vol 22, Iss 1, Pp 1-20 (2022)

Abstract Background Gastric cancer is one of the most common malignancies of the digestive system with a high lethal rate. Studies have shown that inherited and acquired mutations in pyruvate metabolism and citric acid cycle (P-CA) enzymes are involv

Externí odkaz: https://doaj.org/article/cfcbb092648d4ff48402a8be464cca17

Acrylamide Exposure Impairs Ovarian Tricarboxylic Acid Cycle and Reduces Oocyte Quality in Mouse.

Autor: Liu YC; Medical College, Guangxi University, Nanning, Guangxi, China., Li RC; Medical College, Guangxi University, Nanning, Guangxi, China., Wang WK; Medical College, Guangxi University, Nanning, Guangxi, China., Chen YZ; Medical College, Guangxi University, Nanning, Guangxi, China., He QK; Medical College, Guangxi University, Nanning, Guangxi, China., Xu ZR; Translational Medicine Research Center, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China., Yang YF; Medical College, Guangxi University, Nanning, Guangxi, China., Cheng SY; Medical College, Guangxi University, Nanning, Guangxi, China., Wang HL; Department of Basic Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China., Qi ZQ; Medical College, Guangxi University, Nanning, Guangxi, China., Xu CL; Reproductive Medical Center of Nanning Second People's Hospital, Nanning, Guangxi, China., Liu Y; Medical College, Guangxi University, Nanning, Guangxi, China.

Publikováno v: Environmental toxicology [Environ Toxicol] 2024 Nov; Vol. 39 (11), pp. 5074-5085. Date of Electronic Publication: 2024 Jul 31.

TCA metabolism regulates DNA hypermethylation in LPS and Mycobacterium tuberculosis -induced immune tolerance.

Autor: Abhimanyu; Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030., Longlax SC; Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030., Nishiguchi T; Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030., Ladki M; Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030., Sheikh D; Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030., Martinez AL; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030., Mace EM; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032., Grimm SL; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030., Caldwell T; Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030., Portillo Varela A; Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030., Sekhar RV; Translational Metabolism Unit, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030., Mandalakas AM; Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030.; Epidemiology, Human Genetics & Environmental Sciences, University of Texas-UTHealth School of Public Health, Houston, TX 77030.; Clinical Infectious Disease Group, German Center for Infectious Research (DZIF), Clinical tuberculosis (TB) Unit, Research Center Borstel, Borstel 27246, Germany., Mlotshwa M; The Aurum institute, Johannesburg 2006, South Africa.; Department of Biomedical Sciences, Faculty of Health Sciences, University of Johannesburg, Johannesburg 2006, South Africa.; Department of Medicine, Vanderbilt University, Nashville, TN 37232., Ginidza S; The Aurum institute, Johannesburg 2006, South Africa., Cirillo JD; Center for Airborne Pathogen Research and Imaging, Texas A&M College of Medicine, Bryan, TX 77843., Wallis RS; The Aurum institute, Johannesburg 2006, South Africa.; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Vanderbilt Institute for Global Health, Vanderbilt University, Nashville, TN 37232., Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen 6525, Netherlands.; Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn 53113, Germany., van Crevel R; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen 6525, Netherlands.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford OX1 4BH, United Kingdom., Coarfa C; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030., DiNardo AR; Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030.; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen 6525, Netherlands.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Oct 08; Vol. 121 (41), pp. e2404841121. Date of Electronic Publication: 2024 Sep 30.