Zobrazeno 1 - 10
of 253
pro vyhledávání: '"cite-seq"'
Autor:
Nicole S Arellano, Shannon E Elf
Publikováno v:
eLife, Vol 13 (2024)
A new approach helps examine the proportion of cancerous and healthy stem cells in patients with chronic myeloid leukemia and how this influences treatment outcomes.
Externí odkaz:
https://doaj.org/article/4f5a9e5111414f65b282cdebbee7af40
Autor:
Rebecca Warfvinge, Linda Geironson Ulfsson, Parashar Dhapola, Fatemeh Safi, Mikael Sommarin, Shamit Soneji, Henrik Hjorth-Hansen, Satu Mustjoki, Johan Richter, Ram Krishna Thakur, Göran Karlsson
Publikováno v:
eLife, Vol 12 (2024)
The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI-insensitive leukemia stem cells (LSCs) persist in most patients even after years of
Externí odkaz:
https://doaj.org/article/d2afc990e3264278aae9d3f9ec4607bc
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Multimodal integration combines information from different sources or modalities to gain a more comprehensive understanding of a phenomenon. The challenges in multi-omics data analysis lie in the complexity, high dimensionality, and heteroge
Externí odkaz:
https://doaj.org/article/1b1291cda47649f4a6da91973244af06
Autor:
Garth L. Kong, Thai T. Nguyen, Wesley K. Rosales, Anjali D. Panikar, John H. W. Cheney, Theresa A. Lusardi, William M. Yashar, Brittany M. Curtiss, Sarah A. Carratt, Theodore P. Braun, Julia E. Maxson
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background The rapid advancement of new genomic sequencing technology has enabled the development of multi-omic single-cell sequencing assays. These assays profile multiple modalities in the same cell and can often yield new insights not rev
Externí odkaz:
https://doaj.org/article/5f9df1b734eb426b9479c83d4a912b37
Autor:
Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Saleh Alrhmoun, Marina Volynets, Julia Shevchenko, Kirill Nazarov, Vera Denisova, Sergey Sennikov
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The role of Erythroid cells in immune regulation and immunosuppression is one of the emerging topics in modern immunology that still requires further clarification as Erythroid cells from different tissues and different species express different immu
Externí odkaz:
https://doaj.org/article/0328485e0ad6475eb66a105025eafe4a
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/69ca9c3597b14fbb8be71fc2e2d9eee2
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionB cells play a pivotal role in adaptive immunity which has been extensively characterised primarily via flow cytometry-based gating strategies. This study addresses the discrepancies between flow cytometry-defined B cell subsets and their
Externí odkaz:
https://doaj.org/article/69c71e4ec42143c390e293b6fcc468ac
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background Microglia have been implicated in the pathophysiology of neuropathic pain. Here, we sought to investigate whether cerebrospinal fluid (CSF) might be used as a proxy-measure of microglial activation in human participants. Methods We preform
Externí odkaz:
https://doaj.org/article/b5d46889ba74449eab89e5c5d04067df
Autor:
Joshua A. Regal, María E. Guerra García, Vaibhav Jain, Vidyalakshmi Chandramohan, David M. Ashley, Simon G. Gregory, Eric M. Thompson, Giselle Y. López, Zachary J. Reitman
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-30 (2023)
Abstract Gangliogliomas are brain tumors composed of neuron-like and macroglia-like components that occur in children and young adults. Gangliogliomas are often characterized by a rare population of immature astrocyte-appearing cells expressing CD34,
Externí odkaz:
https://doaj.org/article/d9a27d880bbe4ad09edb99a558ed71db
Autor:
Huan Hu, Ruiqi Liu, Chunlin Zhao, Yuer Lu, Yichun Xiong, Lingling Chen, Jun Jin, Yunlong Ma, Jianzhong Su, Zhengquan Yu, Feng Cheng, Fangfu Ye, Liyu Liu, Qi Zhao, Jianwei Shuai
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 290-304 (2022)
Simultaneous measurement of multiple modalities in single-cell analysis, represented by CITE-seq, is a promising approach to link transcriptional changes to cellular phenotype and function, requiring new computational methods to define cellular subty
Externí odkaz:
https://doaj.org/article/78bfb6a63bad43fb8e22c103bf13eb69