Zobrazeno 1 - 10
of 660
pro vyhledávání: '"chronic social defeat"'
Autor:
Fabiënne S. Meijboom, Annika Hasch, Inigo Ruiz de Azua, Camila Takeno Cologna, Shauni Loopmans, Beat Lutz, Marianne B. Müller, Bart Ghesquière, Michael A. van der Kooij
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Chronic stress has been shown to induce hyperglycemia in both peripheral blood and the brain, yet the detailed mechanisms of glucose metabolism under stress remain unclear. Utilizing 13C6-labeled glucose to trace metabolic pathways, our stud
Externí odkaz:
https://doaj.org/article/80b1bf145d9b43e2ada168a7d2da9842
Autor:
Man Han, Deyang Zeng, Wei Tan, Xingxing Chen, Shuyuan Bai, Qiong Wu, Yushan Chen, Zhen Wei, Yufei Mei, Yan Zeng
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 1, Pp 159-173 (2025)
Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response. Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific, part
Externí odkaz:
https://doaj.org/article/f81afcfbe4b9470e81fff5fc4c56ba39
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Major depressive disorder (MDD), characterized by severe neuropsychiatric symptoms and significant cognitive deficits, continues to present both etiological and therapeutic challenges. However, the specific underlying mechanisms and the
Externí odkaz:
https://doaj.org/article/d4f222ff786e4a4ab223261286dd69f4
Publikováno v:
陆军军医大学学报, Vol 46, Iss 8, Pp 775-785 (2024)
Objective To investigate the potential pathogenesis of depression and the improving effect of glutathione (GSH) in the process. Methods Sixty male C57BL/6J mice (6-8 weeks old) were randomly divided into sham operation group (SHAM), post-stroke depre
Externí odkaz:
https://doaj.org/article/f7a0d2533af845138226df9d2061894a
Autor:
Alessia Costa, Laura Micheli, Virginia Sordi, Clara Ciampi, Jacopo Lucci, Maria Beatrice Passani, Gustavo Provensi
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Prolonged exposure to stress is a risk factor for the onset of several disorders. Modern life is burdened by a pervasive prevalence of stress, which represents a major societal challenge requiring new therapeutic strategies. In this conte
Externí odkaz:
https://doaj.org/article/91c34079a7d34a6f89a74312849d91d5
Autor:
Xi Chen, Qian-Qian Cui, Xiao-Hai Hu, Jian Ye, Zi-Cun Liu, Yuan-Xi Mei, Fang Wang, Zhuang-Li Hu, Jian-Guo Chen
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Background Neuroinflammation and microglia play critical roles in the development of depression. Cluster of differentiation 200 (CD200) is an anti-inflammatory glycoprotein that is mainly expressed in neurons, and its receptor CD200R1 is pri
Externí odkaz:
https://doaj.org/article/38e44c83736f4795924507022a86398f
Publikováno v:
Exploration, Vol 3, Iss 6, Pp n/a-n/a (2023)
Abstract Depression is a highly prevalent and disabling mental disorder, involving numerous genetic changes that are associated with abnormal functions in multiple regions of the brain. However, there is little transcriptomic‐wide characterization
Externí odkaz:
https://doaj.org/article/f6a35fc2aa8b49a185de4f6df51dc78f
Autor:
Min Cai, Yingbo Zhu, Mary Regis Shanley, Carole Morel, Stacy M. Ku, Hongxing Zhang, Yuan Shen, Allyson K. Friedman, Ming-Hu Han
Publikováno v:
Neurobiology of Stress, Vol 26, Iss , Pp 100565- (2023)
Repeated, long-term (weeks to months) exposure to standard antidepressant medications is required to achieve treatment efficacy. In contrast, acute ketamine quickly improves mood for an extended time. Recent work implicates that hyperpolarization-act
Externí odkaz:
https://doaj.org/article/2ead91ec8e4545f393f903b88152f259
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