Zobrazeno 1 - 10
of 839
pro vyhledávání: '"chromosome organization"'
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110869- (2024)
Summary: Lamins A and C are components of the lamina at the nuclear periphery and associate with heterochromatin. A distinct, relatively mobile pool of lamin A/C in the nuclear interior associates with euchromatic regions and with lamin-associated po
Externí odkaz:
https://doaj.org/article/9d6576f138ed4b15a1ee50bf4bdb5dbc
Autor:
Georgi Danovski, Greta Panova, Bradley Keister, Georgi Georgiev, Aleksandar Atemin, Sonya Uzunova, Rumen Stamatov, Petar-Bogomil Kanev, Radoslav Aleksandrov, Krastan B. Blagoev, Stoyno S. Stoynov
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110826- (2024)
Summary: During DNA repair, ATM-induced H2AX histone phosphorylation and MDC1 recruitment spread megabases beyond the damage site. While loop extrusion has been suggested to drive this spread, the underlying mechanism remains unclear. Herein, we prov
Externí odkaz:
https://doaj.org/article/14a8058a4f0c4a75968a8af700c246cf
Autor:
Debora Keller, Sonia Stinus, David Umlauf, Edith Gourbeyre, Eric Biot, Nicolas Olivier, Pierre Mahou, Emmanuel Beaurepaire, Philippe Andrey, Laure Crabbe
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109343- (2024)
Summary: Spatial genome organization within the nucleus influences major biological processes and is impacted by the configuration of linear chromosomes. Here, we applied 3D spatial statistics and modeling on high-resolution telomere and centromere 3
Externí odkaz:
https://doaj.org/article/56dab50fd97b44fab26e59dcc95207fe
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109007- (2024)
Summary: Chromosomal instability (CIN) is a hallmark of cancers, and CIN-promoting mutations are not fully understood. Here, we report 141 chromosomal instability aiding variant (CIVa) candidates by assessing the prevalence of loss-of-function (LoF)
Externí odkaz:
https://doaj.org/article/1e0e32715fda4fc48c04d567eae83dec
Autor:
Jhen Yuan Yang, Jia-Ming Chang
Publikováno v:
BMC Bioinformatics, Vol 22, Iss S10, Pp 1-15 (2022)
Abstract Background Recent increasing evidence indicates that three-dimensional chromosome structure plays an important role in genomic function. Topologically associating domains (TADs) are self-interacting regions that have been shown to be a chrom
Externí odkaz:
https://doaj.org/article/f8432215efd744449986f19f08a4dc70
Akademický článek
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Akademický článek
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Autor:
Sanjana Sundararajan, Hyewon Park, Shinji Kawano, Marnie Johansson, Bunu Lama, Tomoko Saito-Fujita, Noriko Saitoh, Alexei Arnaoutov, Mary Dasso, Zhengqiang Wang, Daniel Keifenheim, Duncan J. Clarke, Yoshiaki Azuma
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106743- (2023)
Summary: DNA Topoisomerase IIα (TopoIIα) decatenates sister chromatids, allowing their segregation in mitosis. Without the TopoIIα Strand Passage Reaction (SPR), chromosome bridges and ultra-fine DNA bridges (UFBs) arise in anaphase. The TopoIIα
Externí odkaz:
https://doaj.org/article/19bb8937fd674b67b4767f3d9fe007bf
Autor:
Zhenfeng Zhang, Salvatore Fusco
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/68a7d670afa64d05aa64c0cacd0c07c1
Autor:
Sara Priego Moreno, Javier Miralles Fusté, Melanie Kaiser, Julia Su Zhou Li, Joe Nassour, Candy Haggblom, Eros Lazzerini Denchi, Jan Karlseder
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106405- (2023)
Summary: The appropriate regulation of telomere length homeostasis is crucial for the maintenance of genome integrity. The telomere-binding protein TZAP has been suggested to regulate telomere length by promoting t-circle and c-circle excisions throu
Externí odkaz:
https://doaj.org/article/8bf0cd1dfa674cda89cdbca6828530fd