Zobrazeno 1 - 10
of 7 721
pro vyhledávání: '"chromosome instability"'
Autor:
María Yolanda Buitrago-Rodríguez, Nelson Rangel, Juan D. Vega-Valderrama, Martín Pulido-Medellín, Milena Rondón-Lagos
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
PurposeCoal mining is a vital sector in Colombia, contributing significantly to the nation’s economy and the development of its regions. However, despite its importance, it has led to a gradual decline in the health of mine workers and nearby resid
Externí odkaz:
https://doaj.org/article/ff52d75a8a0f456486dd7e4d19e35dcf
Autor:
Ioannis A. Voutsadakis
Publikováno v:
Diseases, Vol 12, Iss 10, p 234 (2024)
Background: Colorectal cancer, a prevalent gastrointestinal carcinoma, has a high risk for recurrence when locally advanced and remains lethal when in an advanced stage. Prognostic biomarkers may help in better delineating the aggressiveness of this
Externí odkaz:
https://doaj.org/article/7089143879aa4bb8ae4a2c75d0bab563
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Background:The diagnosis of Precancerous Lesions of Gastric Cancer (PLGC) is challenging in clinical practice. We conducted a clinical study by analyzing the information of relevant chromosome copy number variations (CNV) in the TCGA database followe
Externí odkaz:
https://doaj.org/article/f3f46b882e5f48f7bf279832b691b5a0
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Kinesin motors are a large family of molecular motors that walk along microtubules to fulfill many roles in intracellular transport, microtubule organization, and chromosome alignment. Kinesin-7 CENP-E (Centromere protein E) is a chromosome scaffold-
Externí odkaz:
https://doaj.org/article/0c8cfefa2ff24093b1a5a956d196f7f8
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Toxoplasma gondii is a globally occurring apicomplexan parasite that infects humans and animals. Globally, different typical and atypical haplotypes of T. gondii induce varying pathologies in hosts. As an obligate intracellular protozoon, T. gondii w
Externí odkaz:
https://doaj.org/article/4447c5d391d142b7a9194b2e0908e0bb
Akademický článek
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Autor:
Andrzej Kasperski, Henry H. Heng
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9163 (2024)
If one must prioritize among the vast array of contributing factors to cancer evolution, environmental-stress-mediated chromosome instability (CIN) should easily surpass individual gene mutations. CIN leads to the emergence of genomically unstable li
Externí odkaz:
https://doaj.org/article/b07c90655b664ec29be04ffb3b356387
Publikováno v:
Cells, Vol 13, Iss 16, p 1397 (2024)
The AurkA serine/threonine kinase is a key regulator of cell division controlling mitotic entry, centrosome maturation, and chromosome segregation. The microtubule-associated protein TPX2 controls spindle assembly and is the main AurkA regulator, con
Externí odkaz:
https://doaj.org/article/4db7a0f256614324aedbe0b026bcd806
Autor:
Katherine L. Schutt, Katelyn A. Queen, Kira Fisher, Olivia Budington, Weifeng Mao, Wei Liu, Xiaohui Gu, Yisong Xiao, Fred Aswad, James Joseph, Jason Stumpff
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Background: The mitotic kinesin, KIF18A, is required for proliferation of cancer cells that exhibit chromosome instability (CIN), implicating it as a promising target for treatment of a subset of aggressive tumor types. Determining regions of the KIF
Externí odkaz:
https://doaj.org/article/cc433fd5932f40ad91df8b3c7b187486
Autor:
Yurong Song, Travis D. Kerr, Chelsea Sanders, Lisheng Dai, Shaneen S. Baxter, Brandon Somerville, Ryan N. Baugher, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn, Teri M. Plona, Bingfang Xu, Lei Wei, Qiang Hu, Song Liu, Alan Hutson, Baktiar Karim, Sandra Burkett, Simone Difilippantonio, Ligia Pinto, Johannes Gebert, Matthias Kloor, Steven M. Lipkin, Shizuko Sei, Robert H. Shoemaker
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundGenome integrity is essential for the survival of an organism. DNA mismatch repair (MMR) genes (e.g., MLH1, MSH2, MSH6, and PMS2) play a critical role in the DNA damage response pathway for genome integrity maintenance. Germline mutations o
Externí odkaz:
https://doaj.org/article/0d2e5d6b71eb4b909e5643961c4ff61e