Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma

Autor: Kaylee M. Keller, Thomas F. Eleveld, Linda Schild, Kim van den Handel, Marlinde van den Boogaard, Vicky Amo-Addae, Selma Eising, Kimberley Ober, Bianca Koopmans, Leendert Looijenga, Godelieve A.M. Tytgat, Bauke Ylstra, Jan J. Molenaar, M. Emmy M. Dolman, Sander R. van Hooff

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Neuroblastoma is the most common extracranial solid tumor found in children and despite intense multi-modal therapeutic approaches, low overall survival rates of high-risk patients persist. Tumors with heterozygous loss of chromosome 11q and MYCN amp

Externí odkaz: https://doaj.org/article/2046bd60d71d42bd8c11809b13f2595a

Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma

Autor: Keller, Kaylee M., Eleveld, Thomas F., Schild, Linda, van den Handel, Kim, van den Boogaard, Marlinde, Amo-Addae, Vicky, Eising, Selma, Ober, Kimberley, Koopmans, Bianca, Looijenga, Leendert, Tytgat, Godelieve A.M., Ylstra, Bauke, Molenaar, Jan J., Dolman, M. Emmy M., van Hooff, Sander R., Afd Pharmaceutics, Pharmaceutics

Publikováno v: Frontiers in Oncology, 12, 1. Frontiers Media S.A.
Frontiers in Oncology, 12:929123. Frontiers Media S.A.
Frontiers in oncology, 12:929123. Frontiers Media S.A.
Keller, K M, Eleveld, T F, Schild, L, van den Handel, K, van den Boogaard, M, Amo-Addae, V, Eising, S, Ober, K, Koopmans, B, Looijenga, L, Tytgat, G A M, Ylstra, B, Molenaar, J J, Dolman, M E M & van Hooff, S R 2022, ' Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma ', Frontiers in Oncology, vol. 12, 929123 . https://doi.org/10.3389/fonc.2022.929123

Neuroblastoma is the most common extracranial solid tumor found in children and despite intense multi-modal therapeutic approaches, low overall survival rates of high-risk patients persist. Tumors with heterozygous loss of chromosome 11q and MYCN amp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329aea7d7c7654768bccaddc20ad5c25
https://dspace.library.uu.nl/handle/1874/425877

Prenatal diagnosis of a de novo interstitial deletion of 11q (11q22.3 → q23.3) associated with abnormal ultrasound findings by array comparative genomic hybridization

Autor: Nian Liu, Bo Wang, Xinlin Chen, Yanyi Yao, Jieping Song, Jiong Yan

Publikováno v: Molecular Cytogenetics

Background Conventional G-band karyotyping offers low-resolution detection of chromosome abnormalities and cannot provide information about the involved genomic content. On the other hand, array comparative genomic hybridization can offer a rapid and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64317be72616f9ad59f061b3161cd34a
http://europepmc.org/articles/PMC4189608

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