Zobrazeno 1 - 10
of 57
pro vyhledávání: '"chromosomal architecture"'
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Genetic variants showing associations with specific biological traits and diseases detected by genome-wide association studies (GWAS) commonly map to non-coding DNA regulatory regions. Many of these regions are located considerable distances away fro
Externí odkaz:
https://doaj.org/article/502ff5588bf84dc98184cb382a6f0b34
Autor:
Martin A. Rivas, Ceyda Durmaz, Andreas Kloetgen, Cristopher R. Chin, Zhengming Chen, Bhavneet Bhinder, Amnon Koren, Aaron D. Viny, Christopher D. Scharer, Jeremy M. Boss, Olivier Elemento, Christopher E. Mason, Ari M. Melnick
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The cohesin complex plays critical roles in genomic stability and gene expression through effects on 3D architecture. Cohesin core subunit genes are mutated across a wide cross-section of cancers, but not in germinal center (GC) derived lymphomas. In
Externí odkaz:
https://doaj.org/article/d81425a378284c1c898ba5565c38ac34
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Both intrinsic and extrinsic mechanisms regulating bacterial expression have been elucidated and described, however, such studies have mainly focused on local effects on the two-dimensional structure of the prokaryote genome while long-range as well
Externí odkaz:
https://doaj.org/article/45ea91bd4e7f4311923f15f1ff2f1321
Autor:
Yue Huang, Olivia I. Koues, Jiang-yang Zhao, Regina Liu, Sarah C. Pyfrom, Jacqueline E. Payton, Eugene M. Oltz
Publikováno v:
Cell Reports, Vol 18, Iss 12, Pp 2918-2931 (2017)
Alterations in distal regulatory elements that control gene expression underlie many diseases, including cancer. Epigenomic analyses of normal and diseased cells have produced correlative predictions for connections between dysregulated enhancers and
Externí odkaz:
https://doaj.org/article/293a92f83fe243ecb1bdc8e9f17a1cc0
Copyright © 2023 Goodall, Warecka, Hawkins and Rudolph. Faithful transmission of the genome from one generation to the next is key to life in all cellular organisms. In the majority of bacteria, the genome is comprised of a single circular chromosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______900::8adc8857ce7a231891f738ad97a688bc
https://bura.brunel.ac.uk/handle/2438/26747
https://bura.brunel.ac.uk/handle/2438/26747
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
The bacterial nucleoid is highly condensed and forms compartment-like structures within the cell. Much attention has been devoted to investigating the dynamic topology and organization of the nucleoid. In contrast, the specific nucleoid organization,
Externí odkaz:
https://doaj.org/article/ce179143d62b4838869cd4d4972e3b98
Autor:
Magdalena Steinrueck, Călin C Guet
Publikováno v:
eLife, Vol 6 (2017)
How the organization of genes on a chromosome shapes adaptation is essential for understanding evolutionary paths. Here, we investigate how adaptation to rapidly increasing levels of antibiotic depends on the chromosomal neighborhood of a drug-resist
Externí odkaz:
https://doaj.org/article/1e4a480e98b7409c8da8e40a08ec89a5
Publikováno v:
Genes
Genes, 2022, 13 (7), pp.1244. ⟨10.3390/genes13071244⟩
Genes; Volume 13; Issue 7; Pages: 1244
Genes, 2022, 13 (7), pp.1244. ⟨10.3390/genes13071244⟩
Genes; Volume 13; Issue 7; Pages: 1244
International audience; Eukaryotic DNA replication is regulated by conserved mechanisms that bring about a spatial and temporal organization in which distinct genomic domains are copied at characteristic times during S phase. Although this replicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7848be6864e5dc12af9d73b246c348d
https://pubmed.ncbi.nlm.nih.gov/35886027
https://pubmed.ncbi.nlm.nih.gov/35886027
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 7928, p 7928 (2021)
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 7928, p 7928 (2021)
Copyright: © 2021 by the authors. Termination of DNA replication, the final stage of genome duplication, is surprisingly complex, and failures to bring DNA synthesis to an accurate conclusion can impact genome stability and cell viability. In Escher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6653d8c5993f5a65da51fc7bead064dc
https://bura.brunel.ac.uk/handle/2438/23004
https://bura.brunel.ac.uk/handle/2438/23004
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