Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation

Autor: Alex F Thompson, Patrick R Blackburn, Noah S Arons, Sarah N Stevens, Dusica Babovic-Vuksanovic, Jane B Lian, Eric W Klee, Jason Stumpff

Publikováno v: eLife, Vol 11 (2022)

The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the i

Externí odkaz: https://doaj.org/article/8723f0c9edc84db2b8e75bfe755aa234

The Chromokinesin Kid Is Necessary for Chromosome Arm Orientation and Oscillation, but Not Congression, on Mitotic Spindles

Autor: Levesque, Aime A., Compton, Duane A.

Publikováno v: The Journal of Cell Biology, 2001 Sep . 154(6), 1135-1146.

Externí odkaz: https://www.jstor.org/stable/1620698

Importin-β and the Small Guanosine Triphosphatase Ran Mediate Chromosome Loading of the Human Chromokinesin Kid

Autor: Tahara, Kiyoshi, Takagi, Masatoshi, Ohsugi, Miho, Sone, Takefumi, Nishiumi, Fumiko, Maeshima, Kazuhiro, Horiuchi, Yasuomi, Tokai-Nishizumi, Noriko, Imamoto, Fumio, Yamamoto, Tadashi, Kose, Shingo, Imamoto, Naoko

Publikováno v: The Journal of Cell Biology, 2008 Feb 01. 180(3), 493-506.

Externí odkaz: https://www.jstor.org/stable/20475784

Quantifying Changes in Chromosome Position to Assess Chromokinesin Activity.

Autor: Thompson AF; Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, USA., Vandal S; Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, USA., Stumpff J; Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, USA. jstumpff@uvm.edu.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2415, pp. 139-149.

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