Zobrazeno 1 - 10
of 813
pro vyhledávání: '"chromatin state"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2240-2250 (2024)
The 3D conformations of chromosomes can encode biological significance, and the implications of such structures have been increasingly appreciated recently. Certain chromosome structural features, such as A/B compartmentalization, are frequently extr
Externí odkaz:
https://doaj.org/article/0c0697b30ae44fc49d46b7a871f4414d
Publikováno v:
Animal Cells and Systems, Vol 28, Iss 1, Pp 75-83 (2024)
ABSTRACTThe CRISPR-Cas system stands out as a promising genome editing tool due to its cost-effectiveness and time efficiency compared to other methods. This system has tremendous potential for treating various diseases, including genetic disorders a
Externí odkaz:
https://doaj.org/article/1f6ad6d9de6e420c85787ccc287042b0
Autor:
Saurav Kiri, Tyrone Ryba
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-27 (2024)
Abstract Cancer is the second leading cause of death worldwide and disease burden is expected to increase globally throughout the next several decades, with the majority of cancer-related deaths occurring in metastatic disease. Cancers exhibit known
Externí odkaz:
https://doaj.org/article/e389f34cb1674be183b40b59db7e2d8a
Publikováno v:
Neural Development, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract Background A key step in nervous system development involves the coordinated control of neural progenitor specification and positioning. A long-standing model for the vertebrate CNS postulates that transient anatomical compartments – known
Externí odkaz:
https://doaj.org/article/9fdb219659664d87b4ac1904c6cf33cc
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background The nuclear lamina links the nuclear membrane to chromosomes and plays a crucial role in regulating chromatin states and gene expression. However, current knowledge of nuclear lamina in plants is limited compared to animals and hu
Externí odkaz:
https://doaj.org/article/d882d0d62b144954a1ef3434737d3a25
Publikováno v:
Plant-Environment Interactions, Vol 5, Iss 2, Pp n/a-n/a (2024)
Abstract Leaves are colonized by a complex mix of microbes, termed the leaf microbiota. Even though the leaf microbiota is increasingly recognized as an integral part of plant life and health, our understanding of its interactions with the plant host
Externí odkaz:
https://doaj.org/article/9ff3e8fdbeb3441c81a606e70414a9ee
Autor:
Wonseok Son, Ki Wha Chung
Publikováno v:
FEBS Open Bio, Vol 13, Iss 9, Pp 1658-1666 (2023)
CRISPR mutagenesis is an efficient way to disrupt specific target genes in many model organisms. We previously devised a targeted CRISPR recombination method to generate intragenic recombinants of alleles in Drosophila. Here, we assessed the applicab
Externí odkaz:
https://doaj.org/article/f55c79b134e449e79780df0a0a671a07
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-21 (2022)
Abstract Background It is challenging to determine the effect of DNA methylation on the epigenetic landscape and the function in higher organisms due to the lack of DNA methylation-free mutants. Results Here, the analysis of a recently generated Arab
Externí odkaz:
https://doaj.org/article/421ab35f5627434980f4de1bfff65087
Publikováno v:
PeerJ, Vol 11, p e15961 (2023)
Histone acetylation and deacetylation affect the patterns of gene expression in cellular differentiation, playing pivotal roles in tissue development and maintenance. For example, the intrinsic histone acetyltransferase activity of transcriptional co
Externí odkaz:
https://doaj.org/article/700ebf24550e465080ef8e0e25a08391
Autor:
Bhagyshree Jamge, Zdravko J Lorković, Elin Axelsson, Akihisa Osakabe, Vikas Shukla, Ramesh Yelagandula, Svetlana Akimcheva, Annika Luisa Kuehn, Frédéric Berger
Publikováno v:
eLife, Vol 12 (2023)
How different intrinsic sequence variations and regulatory modifications of histones combine in nucleosomes remain unclear. To test the importance of histone variants in the organization of chromatin we investigated how histone variants and histone m
Externí odkaz:
https://doaj.org/article/dac2ee6289964c7d9ca29f8ff76e2ac6