Enhancer-Promoter Communication: It’s Not Just About Contact

Autor: Annabelle Wurmser, Srinjan Basu

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

Cis-regulatory elements such as enhancers can be located even a million base pairs away from their cognate promoter and yet modulate gene transcription. Indeed, the 3D organisation of chromatin enables the establishment of long-range enhancer-promote

Externí odkaz: https://doaj.org/article/c5484718660844b090d6f514d9122ba8

DNA Double-Strand Break Repair: All Roads Lead to HeterochROMAtin Marks

Autor: Pierre Caron, Enrico Pobega, Sophie E. Polo

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

In response to DNA double-strand breaks (DSBs), chromatin modifications orchestrate DNA repair pathways thus safeguarding genome integrity. Recent studies have uncovered a key role for heterochromatin marks and associated factors in shaping DSB repai

Externí odkaz: https://doaj.org/article/2b4640bdcd6c480e9bbaff2f536e7c07

The plant‐specific DDR factor SOG1 increases chromatin mobility in response to DNA damage

Autor: Anis Meschichi, Lihua Zhao, Svenja Reeck, Charles White, Olivier Da Ines, Adrien Sicard, Frédéric Pontvianne, Stefanie Rosa

Publikováno v: EMBO Reports
EMBO Reports, In press, ⟨10.15252/embr.202254736⟩

International audience; Homologous recombination (HR) is a conservative DNA repair pathway in which intact homologous sequences are used as a template for repair. How the homology search happens in the crowded space of the cell nucleus is, however, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd0dc34afac195d716aede8c6274d05
https://doi.org/10.15252/embr.202254736

H3.3 kinetics predicts chromatin compaction status of parental genomes in early embryos

Autor: Xing-Ping Liu, Li-Quan Zhou, Shi-Meng Guo

Publikováno v: Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-7 (2021)
Reproductive Biology and Endocrinology : RB&E

BackgroundAfter fertilization, the fusion of gametes results in the formation of totipotent zygote. During sperm-egg fusion, maternal factors participate in parental chromatin remodeling. H3.3 is a histone H3 variant that plays essential roles in mou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032f7334864b6abf6a32f1c51bee8a7e
https://doaj.org/article/f061bbdc36354beb8ff5f21707f899d9

ANCHOR: A Technical Approach to Monitor Single-Copy Locus Localization in Planta

Autor: Anis Meschichi, Mathieu Ingouff, Claire Picart, Marie Mirouze, Sophie Desset, Franck Gallardo, Kerstin Bystricky, Nathalie Picault, Stefanie Rosa, Frédéric Pontvianne

Publikováno v: Frontiers in Plant Science
Frontiers in Plant Science, 2021, 12, pp.677849. ⟨10.3389/fpls.2021.677849⟩
Frontiers in Plant Science, Frontiers, 2021, 12, pp.677849. ⟨10.3389/fpls.2021.677849⟩

Together with local chromatin structure, gene accessibility, and the presence of transcription factors, gene positioning is implicated in gene expression regulation. Although the basic mechanisms are expected to be conserved in eukaryotes, less is kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b48bf3cab3d403e22c867fe6ff32fb79
https://zenodo.org/record/6256647