Zobrazeno 1 - 10
of 378
pro vyhledávání: '"chromatin looping"'
Autor:
Shuvra Shekhar Roy, Sulochana Bagri, Soujanya Vinayagamurthy, Avik Sengupta, Claudia Regina Then, Rahul Kumar, Sriram Sridharan, Shantanu Chowdhury
Publikováno v:
eLife, Vol 13 (2024)
Although the role of G-quadruplex (G4) DNA structures has been suggested in chromosomal looping this was not tested directly. Here, to test causal function, an array of G4s, or control sequence that does not form G4s, were inserted within chromatin i
Externí odkaz:
https://doaj.org/article/3bb9a3b8d61b4904ac9999874a8797a8
Autor:
Cecilia Rengifo Rojas, Jil Cercy, Sophie Perillous, Céline Gonthier-Guéret, Bertille Montibus, Stéphanie Maupetit-Méhouas, Astrid Espinadel, Marylou Dupré, Charles C. Hong, Kenichiro Hata, Kazuhiko Nakabayashi, Antonius Plagge, Tristan Bouschet, Philippe Arnaud, Isabelle Vaillant, Franck Court
Publikováno v:
HGG Advances, Vol 5, Iss 2, Pp 100271- (2024)
Summary: It is only partially understood how constitutive allelic methylation at imprinting control regions (ICRs) interacts with other regulation levels to drive timely parental allele-specific expression along large imprinted domains. The Peg13-Kcn
Externí odkaz:
https://doaj.org/article/d7cbd17169d146879f77c972bc9cd96b
Autor:
Scott A. Peslak, Selami Demirci, Vemika Chandra, Byoung Ryu, Saurabh K. Bhardwaj, Jing Jiang, Jeremy W. Rupon, Robert E. Throm, Naoya Uchida, Alexis Leonard, Khaled Essawi, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, Francesca Ferrara, Matthew Wielgosz, Osheiza Abdulmalik, Nicole Hamagami, Paula Germino-Watnick, Anh Le, Rebecca Chu, Malikiya Hinds, Mitchell J. Weiss, Wei Tong, John F. Tisdale, Gerd A. Blobel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 452-465 (2023)
Transcriptional enhancers can be in physical proximity of their target genes via chromatin looping. The enhancer at the β-globin locus (locus control region [LCR]) contacts the fetal-type (HBG) and adult-type (HBB) β-globin genes during correspondi
Externí odkaz:
https://doaj.org/article/32788d42c8a3431085e1147f913baa4b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Enhancers are a class of cis-regulatory elements in the genome that instruct the spatiotemporal transcriptional program. Last decade has witnessed an exploration of non-coding transcripts pervasively transcribed from active enhancers in diverse conte
Externí odkaz:
https://doaj.org/article/9b57f57dad254bf1ba7c2469e4d2b948
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3150-3164 (2021)
The three-dimensional (3D) conformation of chromatin is integral to the precise regulation of gene expression. The 3D genome and genomic variations in non-alcoholic fatty liver disease (NAFLD) are largely unknown, despite their key roles in cellular
Externí odkaz:
https://doaj.org/article/6a39f2cff8ea4349a975e87949c8e339
Autor:
Wei Yu, V. Praveen Chakravarthi, Shaon Borosha, Iman Dilower, Eun Bee Lee, Anamika Ratri, Rebekah R. Starks, Patrick E. Fields, Michael W. Wolfe, M. Omar Faruque, Geetu Tuteja, M. A. Karim Rumi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
SATB homeobox proteins are important regulators of developmental gene expression. Among the stem cell lineages that emerge during early embryonic development, trophoblast stem (TS) cells exhibit robust SATB expression. Both SATB1 and SATB2 act to mai
Externí odkaz:
https://doaj.org/article/3993c28b369849f794c60f49c12137d3
Autor:
Yiran Guo, Gang Greg Wang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The multi-subunit Polycomb Repressive Complex (PRC) 1 and 2 act, either independently or synergistically, to maintain and enforce a repressive state of the target chromatin, thereby regulating the processes of cell lineage specification and organisma
Externí odkaz:
https://doaj.org/article/1ce33219ec774904bee8391d962eb011
Akademický článek
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Autor:
Zihang Yin, Shuang Cui, Song Xue, Yufan Xie, Yefan Wang, Chengling Zhao, Zhiyu Zhang, Tao Wu, Guojun Hou, Wuming Wang, Sheila Q. Xie, Yue Wu, Ya Guo
Publikováno v:
Biology, Vol 12, Iss 8, p 1058 (2023)
Three-dimensional genome organization has been increasingly recognized as an important determinant of the precise regulation of gene expression in mammalian cells, yet the relationship between gene transcriptional activity and spatial subcompartment
Externí odkaz:
https://doaj.org/article/6d1279a105d742fd97d9b639488de7fa
Publikováno v:
Viruses, Vol 15, Iss 5, p 1088 (2023)
Epstein–Barr Virus (EBV) is a human gamma-herpesvirus that is widespread worldwide. To this day, about 200,000 cancer cases per year are attributed to EBV infection. EBV is capable of infecting both B cells and epithelial cells. Upon entry, viral D
Externí odkaz:
https://doaj.org/article/4b4dcd3308374a9fb6d2c1cba4d9c594