Zobrazeno 1 - 10
of 205
pro vyhledávání: '"chromatin conformation capture"'
Autor:
Liora S. Katz, Gabriel Brill, Peng Wang, Luca Lambertini, Pili Zhang, Jonathan M. Haldeman, Hongtao Liu, Christopher B. Newgard, Andrew F. Stewart, Adolfo Garcia-Ocaña, Donald K. Scott
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101848- (2024)
Objective: All forms of diabetes result from insufficient functional β-cell mass. Thus, achieving the therapeutic goal of expanding β-cell mass requires a better mechanistic understanding of how β-cells proliferate. Glucose is a natural β-cell mi
Externí odkaz:
https://doaj.org/article/ca3bb72876334491840e4095754b390d
Autor:
Murray P. Cox, Yanan Guo, David J. Winter, Diya Sen, Nicholas C. Cauldron, Jason Shiller, Ellie L. Bradley, Austen R. Ganley, Monica L. Gerth, Randy F. Lacey, Rebecca L. McDougal, Preeti Panda, Nari M. Williams, Niklaus J. Grunwald, Carl H. Mesarich, Rosie E. Bradshaw
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Phytophthora species are notorious plant pathogens, with some causing devastating tree diseases that threaten the survival of their host species. One such example is Phytophthora agathidicida, the causal agent of kauri dieback – a root and trunk ro
Externí odkaz:
https://doaj.org/article/01390332fb02429695084cf6f33e539f
Akademický článek
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Autor:
Oleg V. Bylino, Airat N. Ibragimov, Filomena Anna Digilio, Ennio Giordano, Yulii V. Shidlovskii
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
A transition from one developmental stage to another is accompanied by activation of developmental programs and corresponding gene ensembles. Changes in the spatial conformation of the corresponding loci are associated with this activation and can be
Externí odkaz:
https://doaj.org/article/04a3d52fbcd44d2096fca83dd9a267c2
Autor:
Mark R. Segal, Kipper Fletez-Brant
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background The spatial configuration of chromosomes is essential to various cellular processes, notably gene regulation, while architecture related alterations, such as translocations and gene fusions, are often cancer drivers. Thus, eliciti
Externí odkaz:
https://doaj.org/article/b2f7ffffb4e742b2ba50d311b051cf4a
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 558-570 (2020)
Mechanisms underlying gene regulation are key to understand how multicellular organisms with various cell types develop from the same genetic blueprint. Dynamic interactions between enhancers and genes are revealed to play central roles in controllin
Externí odkaz:
https://doaj.org/article/34954fafdf7e4bae9d5ccb423ffbd356
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
A constellation of chromosome conformation capture methods (С-methods) are an important tool for biochemical analysis of the spatial interactions between DNA regions that are separated in the primary sequence. All these methods are based on the long
Externí odkaz:
https://doaj.org/article/db78c7aeb0484cae8445ba4818125fe5
Kniha
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Akademický článek
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Autor:
Mark R. Segal, Henrik L. Bengtsson
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-9 (2018)
Abstract Background Three dimensional (3D) genome spatial organization is critical for numerous cellular functions, including transcription, while certain conformation-driven structural alterations are frequently oncogenic. Genome conformation had be
Externí odkaz:
https://doaj.org/article/2b8026b67c2347e4b1b9148f1ac9ccd2