Zobrazeno 1 - 10
of 37 240
pro vyhledávání: '"chondrocyte"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Low fluid shear stress (FSS, ≤ 2 dyn/cm2) has been shown to exert protective effects on chondrocytes, but the underlying molecular mechanisms remain unclear. This study aimed to elucidate the mechanisms by which FSS promotes chondrocyte pr
Externí odkaz:
https://doaj.org/article/ac6933db158240cdababc1a89789f519
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 11, Pp 1530-1537 (2024)
Objective To investigate the effect of fibroblast growth factor receptor 3 (FGFR3) on articular cartilage superficial zone cells (SPZCs). Methods C57 mice were randomly divided into two groups: a sham operated group (sham group) and a group of surgic
Externí odkaz:
https://doaj.org/article/52b13288f66c43caa9880837c992ef7c
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cartilage rarely heals spontaneously once damaged. Osteoarthritis (OA) is the most common degenerative joint disease among the elderly; however, effective treatment for OA is currently lacking. Autologous chondrocyte implantation (ACI), an i
Externí odkaz:
https://doaj.org/article/c8472ec9e67840b396a4d14c38dfd213
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Objective This study investigated the protective effects of low fluid shear stress (FSS ≤ 2 dyn/cm²) against interleukin-1β (IL-1β)-induced chondrocyte apoptosis and explored the underlying molecular mechanisms. Methods Chondrocytes wer
Externí odkaz:
https://doaj.org/article/2fca0dbedc6e45dda393ce0683623e38
Publikováno v:
BioTechniques, Pp 1-10 (2024)
In articular cartilage, zone-specific cellular morphology is a typical characteristic of cartilage tissue, which is related with chondrocyte function, inflammation and osteoarthritis (OA). Chondrocyte hypertrophic phenotype is a criticle physiologica
Externí odkaz:
https://doaj.org/article/ac83b5d36ef6461c9abd960434a09773
Autor:
Rachel H. Koh, Junhee Kim, Jeong-Uk Kim, Seunghyun L. Kim, Arun Kumar Rajendran, Seunghun S. Lee, Heesoo Lee, Joo Hyun Kim, Ji Hoon Jeong, Yongsung Hwang, Jong Woo Bae, Nathaniel S. Hwang
Publikováno v:
Bioactive Materials, Vol 40, Iss , Pp 306-317 (2024)
Osteochondral tissue is a highly specialized and complex tissue composed of articular cartilage and subchondral bone that are separated by a calcified cartilage interface. Multilayered or gradient scaffolds, often in conjunction with stem cells and g
Externí odkaz:
https://doaj.org/article/bb5a1cb3504249b1a75161f260976531
Autor:
Fan Chen, Zian Zhang, Wenzhe Wang, Chang Liu, Zhenchao Huang, Chaoqun Yu, Zhen Jia, Haining Zhang
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-10 (2024)
Abstract Acute cartilage injuries, such as intra-articular fractures and blunt impacts, frequently result in chondrocyte death and extracellular matrix (ECM) degradation, significantly elevating the risk of post-traumatic osteoarthritis (PTOA). Despi
Externí odkaz:
https://doaj.org/article/d57e539be70143feb3e72b23ad2d84ab
Autor:
Qingmei Cheng, Ke He, Junyu Zhu, Xiaoxiao Li, Xuan Wu, Chao Zeng, Guanghua Lei, Ning Wang, Hui Li, Jie Wei
Publikováno v:
Journal of Orthopaedic Translation, Vol 48, Iss , Pp 204-216 (2024)
Background: Memantine, which is an FDA-proven drug for the treatment of dementia, exerts its function by blocking the function of NMDA (N-methyl-D-aspartate) receptor, a calcium-permeable ion channel that reduces cytotoxic calcium overload. Chondrocy
Externí odkaz:
https://doaj.org/article/cc85e0f664004e00a1d8a4c693811e1a
Autor:
Julius Michael Wolfgart, Lea Cathrine Grötzner, Sascha Hemayatkar-Fink, Maik Schwitalle, Florian Christof Bonnaire, Martina Feierabend, Marina Danalache, Ulf Krister Hofmann
Publikováno v:
Journal of Orthopaedic Translation, Vol 48, Iss , Pp 232-243 (2024)
Background: In healthy articular cartilage, chondrocytes are found along arcades of collagen fibers as Single Strings. With onset of cartilage degeneration this pattern changes to Double Strings. In the course of osteoarthritis Small Clusters, and fi
Externí odkaz:
https://doaj.org/article/fb59ad23a07d4a80923f034b82799129
Autor:
Chenhao Shi, Yonggang Fan, Xiusheng Huang, Mingzhe Fan, Lantian Zhao, Huafeng Zhang, Shuangfei Ni
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Low back pain (LBP) is largely attributed to intervertebral disc degeneration (IVDD), of which the endplate changes are an important component. However, the alterations in cell fate and properties within the endplates during degeneration rem
Externí odkaz:
https://doaj.org/article/fa4e03300ed24adea12a3c6ab5665bed