Zobrazeno 1 - 10
of 3 093
pro vyhledávání: '"cholesterol/biosynthesis"'
Autor:
Daniel R. Scoles, Stefan M. Pulst
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
The cGAS-STING innate immunity pathway and the SREBP-activated cholesterol and fatty acid synthesis pathway are abnormally co-regulated in neurodegenerative disease. Activation of STING signaling occurs at the endoplasmic reticulum (ER) membrane with
Externí odkaz:
https://doaj.org/article/d24f3381a6e2490ab0deaaa40a87ca04
Autor:
Yibing Bai, Tongzhou Li, Qinshu Wang, Weiqiang You, Haochen Yang, Xintian Xu, Ziyi Li, Yu Zhang, Chengsong Yan, Lei Yang, Jiaqian Qiu, Yuanhua Liu, Shiyang Chen, Dongfang Wang, Binlu Huang, Kexin Liu, Bao- Liang Song, Zhuozhong Wang, Kang Li, Xin Liu, Guangchuan Wang, Weiwei Yang, Jianfeng Chen, Pei Hao, Zemin Zhang, Zhigang Wang, Zheng-Jiang Zhu, Chenqi Xu
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 2, Pp 334-360 (2024)
Abstract Cancer immunotherapies have achieved unprecedented success in clinic, but they remain largely ineffective in some major types of cancer, such as colorectal cancer with microsatellite stability (MSS CRC). It is therefore important to study tu
Externí odkaz:
https://doaj.org/article/a0b9d1b7b5d2433d90da1229130e43db
Akademický článek
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Autor:
Qi Lv, Yishu Zhang, Wen Gao, Juan Wang, Yaowen Hu, Hongqiong Yang, Ying Xie, Yingshan Lv, Heyuan Zhang, Dapeng Wu, Lihong Hu, Junwei Wang
Publikováno v:
Pharmacological Research, Vol 202, Iss , Pp 107126- (2024)
PD-1 blockade therapy has made great breakthroughs in treatment of multiple solid tumors. However, patients with microsatellite-stable (MSS) colorectal cancer (CRC) respond poorly to anti-PD-1 immunotherapy. Although CRC patients with microstatellite
Externí odkaz:
https://doaj.org/article/805fd831e9a942fb80b94b54dbb502d9
Autor:
Danila Coradini, Federico Ambrogi
Publikováno v:
Exploration of Medicine, Vol 4, Iss 6, Pp 1079-1093 (2023)
Aim: Cholesterol is an essential component of cell membranes and serves as a precursor for several bioactive molecules, including steroid hormones and isoprenoids. Generally supplied by the bloodstream, the de novo cholesterol biosynthesis is activat
Externí odkaz:
https://doaj.org/article/8090b30f95d74899a2f9e09c315013fb
Autor:
Lap Hing Chi, Andrew D. Redfern, Terry C. C. Lim Kam Sian, Ian P. Street, Allan D. Burrows, Suraya Roslan, Roger J. Daly, Robin L. Anderson
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9160 (2024)
We reported previously that in preclinical models, BMP4 is a potent inhibitor of breast cancer metastasis and that high BMP4 protein levels predict favourable patient outcomes. Here, we analysed a breast cancer xenograft with or without enforced expr
Externí odkaz:
https://doaj.org/article/2984da50d0f9416499520a987915c258
Autor:
Qingsong Xia, Fuer Lu, Yu Chen, Jingbin Li, Zhaoyi Huang, Ke Fang, Meilin Hu, Yujin Guo, Hui Dong, Lijun Xu, Jing Gong
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116060- (2024)
Excessive synthesis of triglycerides and cholesterol accelerates the progression of hepatic steatosis in metabolic-associated fatty liver disease (MAFLD). However, the precise mechanism by which 6-gingerol mitigates hepatic steatosis in MAFLD model m
Externí odkaz:
https://doaj.org/article/b387effc22304be49c6b34a4a5639989
Autor:
Jing Zhao, Tadafumi C. Ikezu, Wenyan Lu, Jesse R. Macyczko, Yonghe Li, Laura J. Lewis-Tuffin, Yuka A. Martens, Yingxue Ren, Yiyang Zhu, Yan W. Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo, Guojun Bu
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Background The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer’s disease (AD); however, how it modulates brain homeostasis is not clear. The apoE protein is a major lipid carrier in the brain transporting li
Externí odkaz:
https://doaj.org/article/8961c4038dba4cdca8459cc85838feef
Publikováno v:
Journal of Dairy Science, Vol 106, Iss 8, Pp 5805-5824 (2023)
ABSTRACT: Excessive negative energy balance in early lactation is linked to an increased disease risk but may be mitigated by appropriate nutrition. The liver plays central roles in both metabolism and immunity. Hepatic transcriptomic profiles were c
Externí odkaz:
https://doaj.org/article/54048b75a88241e1abc937b233d43bdd
Autor:
Raimund Dietze, Witold Szymanski, Kaire Ojasalu, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Johannes Graumann, Rolf Müller
Publikováno v:
Cells, Vol 13, Iss 10, p 810 (2024)
Lysophosphatidic acid (LPA) species, prevalent in the tumor microenvironment (TME), adversely impact various cancers. In ovarian cancer, the 18:0 and 20:4 LPA species are selectively associated with shorter relapse-free survival, indicating distinct
Externí odkaz:
https://doaj.org/article/5ea8148ce6c84ceaa25edad6fe6fbbc0