Transferrin-inspired iron delivery across the cell membrane using [(L 2 Fe) 2 (μ-O)] (L = chlorquinaldol) to harness anticancer activity of ferroptosis.

Autor: Abeydeera N; Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu., Mudarmah K; Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu.; On leave from Department of Chemistry, Jazan University, Jazan, 45142, Saudi Arabia., Pant BD; Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu., Krause JA; Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, USA., Zheng YR; Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu., Huang SD; Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu.

Publikováno v: Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2024 Feb 13; Vol. 53 (7), pp. 3206-3214. Date of Electronic Publication: 2024 Feb 13.

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Chlorquinaldol inhibits the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 inflammasome and ameliorates imiquimod-induced psoriasis-like dermatitis in mice.

Autor: Chen Y; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China., Chen X; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China., Liang S; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China., Ou Y; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China., Lin G; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China., Hua L; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China., Wu X; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China., Zhou Y; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China., Liu Z; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China., Cai H; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China., Yang Z; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China. Electronic address: yzj23@gzhmu.edu.cn., Hu W; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China. Electronic address: huwenhui@gzhmu.edu.cn., Sun P; Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China. Electronic address: sun_ping@gzhmu.edu.cn.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2022 Sep 25; Vol. 365, pp. 110122. Date of Electronic Publication: 2022 Aug 21.

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Transferrin-inspired iron delivery across the cell membrane using [(L2Fe)2(μ-O)] (L = chlorquinaldol) to harness anticancer activity of ferroptosis.

Autor: Abeydeera, Nalin¹ (AUTHOR), Mudarmah, Khalil^1,2 (AUTHOR), Pant, Bishnu D.¹ (AUTHOR), Krause, Jeanette A.³ (AUTHOR), Zheng, Yao-Rong¹ (AUTHOR) shuang1@kent.edu, Huang, Songping D.¹ (AUTHOR)

Publikováno v: Dalton Transactions: An International Journal of Inorganic Chemistry. 2/21/2024, Vol. 53 Issue 7, p3206-3214. 9p.