High lumenal chloride in the lysosome is critical for lysosome function

Autor: Kasturi Chakraborty, KaHo Leung, Yamuna Krishnan

Publikováno v: eLife, Vol 6 (2017)

Lysosomes are organelles responsible for the breakdown and recycling of cellular machinery. Dysfunctional lysosomes give rise to lysosomal storage disorders as well as common neurodegenerative diseases. Here, we use a DNA-based, fluorescent chloride

Externí odkaz: https://doaj.org/article/be099f8ddf4c4754a8bd28cde44af06d

High lumenal chloride in the lysosome is critical for lysosome function.

Autor: Chakraborty K; Department of Chemistry, University of Chicago, Chicago, United States.; Grossman Institute of Neuroscience, Quantitative Biology and Human Behavior, University of Chicago, Chicago, United States., Leung K; Department of Chemistry, University of Chicago, Chicago, United States.; Grossman Institute of Neuroscience, Quantitative Biology and Human Behavior, University of Chicago, Chicago, United States., Krishnan Y; Department of Chemistry, University of Chicago, Chicago, United States.; Grossman Institute of Neuroscience, Quantitative Biology and Human Behavior, University of Chicago, Chicago, United States.

Publikováno v: ELife [Elife] 2017 Jul 25; Vol. 6. Date of Electronic Publication: 2017 Jul 25.